ArticleBritish journal of clinical pharmacology2005
Allometric relationships between the pharmacokinetics of propofol in rats, children and adults.
Article in British journal of clinical pharmacology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 78 citations in OpenAlex.
- Pharmacokinetic Time Course Scaling of a Subcutaneously Administered Pegylated Peptide Conjugate for a First-in-Human Investigation.European journal of drug metabolism and pharmacokinetics · 2017Trial
- Subthalamic CaMKIIα-expressing neurons facilitate recovery from propofol anesthesia via the STN-ventral pallidum pathway.Cell biology and toxicology · 2026Article
- Prediction of first-in-human dose for new composition bee venom based on allometric scaling and pharmacokinetic modeling approach.Translational and clinical pharmacology · 2025Article
- Population Pharmacokinetic-Pharmacodynamic Modeling of Granulocyte Colony-Stimulating Factor to Optimize Dosing and Timing for CD34Clinical and translational science · 2025Article
- The safety of high dose continuous propofol infusion in the pediatric intensive care unit at an academic medical center.Frontiers in pediatrics · 2025Article
- Criticality supports cross-frequency cortical-thalamic information transfer during conscious states.eLife · 2024Article
- Scaling Pharmacodynamics from Rats to Humans to Support Erythropoietin and Romiplostim Combination Therapy to Treat Erythropoietin-Resistant Anemia.Pharmaceutics · 2023Article
- Influence of body fatness on propofol requirements for loss of consciousness in target-controlled infusion: A STROBE-compliant study.Medicine · 2022Observational
- Wide size dispersion and use of body composition and maturation improves the reliability of allometric exponent estimates.Journal of pharmacokinetics and pharmacodynamics · 2022Article
- Rehydration of the sleeping chironomid, Polypedilum vanderplanki Hinton, 1951 larvae from cryptobiotic state up to full physiological hydration (Diptera: Chironomidae).Scientific reports · 2022Article
- Quantitative Comparison of Avian and Mammalian Physiologies for Parameterization of Physiologically Based Kinetic Models.Frontiers in physiology · 2022Article
- Intravenous ketamine for long term anesthesia in rats.Heliyon · 2020Article
- Mechanistic Multilayer Quantitative Model for Nonlinear Pharmacokinetics, Target Occupancy and Pharmacodynamics (PK/TO/PD) Relationship of D-Amino Acid Oxidase Inhibitor, TAK-831 in Mice.Pharmaceutical research · 2020Article
- Allometric analysis of tylosin tartrate pharmacokinetics in growing male turkeys.Journal of veterinary science · 2020Article
- Control Theory and Cancer Chemotherapy: How They Interact.Frontiers in bioengineering and biotechnology · 2020Review
- Clinical Pharmacokinetics and Pharmacodynamics of Propofol.Clinical pharmacokinetics · 2018Review
- Brain changes due to hypoxia during light anaesthesia can be prevented by deepening anaesthesia; a study in rats.PloS one · 2018Article
- Using Data from Macaques To Predict Gamma Interferon Responses after Mycobacterium bovis BCG Vaccination in Humans: a Proof-of-Concept Study of Immunostimulation/Immunodynamic Modeling Methods.Clinical and vaccine immunology : CVI · 2017Article
- Clinical Pharmacology Studies in Critically Ill Children.Pharmaceutical research · 2017Review
- Prediction of Antimalarial Drug Clearance in Children: A Comparison of Three Different Interspecies Scaling Methods.European journal of drug metabolism and pharmacokinetics · 2016Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsAllometric equations have proven useful for the extrapolation of animal data to determine pharmacokinetic parameters in man. It has been proposed that these equations are also applicable over the human size range including the paediatric population. The aim of this work was to study the relationship between various pharmacokinetic parameters for propofol and body weight using data from rats, children and adults. Furthermore, the utility of allometric scaling is evaluated by the prediction of propofol concentrations in humans based on data obtained in the rat.
methodsThe relationship between the pharmacokinetic parameters of propofol obtained in rats, children and adults was analyzed by plotting the logarithmically transformed parameters against the corresponding logarithmically transformed body weights. In addition, based on allometric equations, pharmacokinetic parameters obtained in rats were scaled to humans. These parameters were used to simulate propofol concentrations in long-term sedated critically ill patients using NONMEM. Simulated concentrations were then compared with actually observed concentrations in humans.
resultsThe relationship between pharmacokinetic parameters of propofol from rats, children and adults was in good agreement with those from the literature on allometric modelling. For clearance, intercompartmental clearance, central volume of distribution and peripheral volume of distribution, the power parameters were 0.78, 0.73, 0.98 and 1.1, respectively, and r2 values for the linear correlations were 0.990, 0.983, 0.977 and 0.994, respectively. On the basis of data obtained after a single bolus injection in the rat, adequate predictions of propofol concentrations in critically ill patients can be made using allometric equations, despite the long-term nature of the use of the drug, the large number of infusion changes per day and/or differences in state of health and age.
conclusionsFor propofol, allometric scaling has proved to be valuable for cross species extrapolation. Furthermore, the use of the allometric equation between adults and children seems to be an adequate tool for the development of rational dosing schemes for children of varying body weights, and requires further study.
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