ArticlePediatric nephrology (Berlin, Germany)2005
Cyclosporin A therapy for severe Henoch-Schönlein nephritis with nephrotic syndrome.
Article in Pediatric nephrology (Berlin, Germany), 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 63 citations in OpenAlex.
- Cyclosporine A vs. methylprednisolone for Henoch-Schönlein nephritis: a randomized trial.Pediatric nephrology (Berlin, Germany) · 2011Trial
- Bibliometric analysis of IgA vasculitis nephritis in children from 2000 to 2022.Frontiers in public health · 2022Article
- Treatment of refractory IgA vasculitis with dapsone: a systematic review.Clinical and experimental pediatrics · 2020Article
- Methylprednisolone or cyclosporine a in the treatment of Henoch-Schönlein nephritis: a nationwide study.Pediatric nephrology (Berlin, Germany) · 2019Article
- Significance of histological crescent formation in patients with IgA vasculitis (Henoch-Schönlein purpura)-related nephritis: a cohort in the adult Chinese population.BMC nephrology · 2018Article
- Successful Treatment of IgA Vasculitis Complicated with Bowel Perforation and Crescentic Glomerulonephritis by Combination Therapy of Glucocorticoid, Cyclosporine and Factor XIII Replacement.Internal medicine (Tokyo, Japan) · 2018Article
- The significance of tubulointerstitial lesions in childhood Henoch-Schönlein nephritis.Pediatric nephrology (Berlin, Germany) · 2016Article
- Clinical features and outcomes of diffuse endocapillary proliferation Henoch-Schönlein purpura nephritis in children.Clinics (Sao Paulo, Brazil) · 2016Article
- Chapter 11: Henoch-Schönlein purpura nephritis.Kidney international supplements · 2012Article
- [Henoch-Schönlein purpura : most frequent form of vasculitis in childhood and adolescence].Zeitschrift fur Rheumatologie · 2011Article
- Cyclosporin A therapy for Henoch-Schönlein nephritis with nephrotic-range proteinuria.Pediatric nephrology (Berlin, Germany) · 2011Article
- Early treatment with methylprednisolone pulse therapy combined with tonsillectomy for heavy proteinuric henoch-schönlein purpura nephritis in children.Nephron extra · 2011Article
- Massive lower gastrointestinal haemorrhage, successfully treated with corticosteroids, as main symptom of Schönlein-Henoch purpura.Rheumatology international · 2009Article
- Treatment-based literature of Henoch-Schönlein purpura nephritis in childhood.Pediatric nephrology (Berlin, Germany) · 2009Review
- Abrupt and durable remission of Henoch-Schönlein purpura nephritis with cyclosporine A.NDT plus · 2008Article
- Gastrointestinal manifestations of Henoch-Schonlein Purpura.Digestive diseases and sciences · 2008Review
- Treating severe Henoch-Schönlein and IgA nephritis with plasmapheresis alone.Pediatric nephrology (Berlin, Germany) · 2007Article
- Methylprednisolone and cyclosporin therapy in a patient with nephrotic proteinuria.Indian journal of pediatrics · 2007Article
- Factors affecting histological regression of crescentic Henoch-Schönlein nephritis in children.Pediatric nephrology (Berlin, Germany) · 2006Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To evaluate the efficacy of cyclosporin A (CyA) for treating severe Henoch-Schönlein nephritis (HSN), seven patients with nephrotic syndrome, aged 3.9-13.8 years (mean 6.5 years), were analyzed retrospectively. Mean follow-up times were 5.5 years (range 2-9 years). All underwent renal biopsy before treatment, and follow-up renal biopsy was performed in six of the seven patients. All patients improved, with 24-h protein declining from a mean of 9.2 g/m(2)/day (range 1.5-16 g/m(2)/day) to 0.3 g/m(2)/day (range 0.03-1.2 g/m(2)/day) (p=0.016) and serum albumin increasing from a mean of 2.1 g/dl (range 1.5-2.4 g/dl) to 4.6 g/dl (range 3.5-5.3 g/dl) (p=0.016) after CyA therapy. The activity index decreased significantly at the second renal biopsies obtained at a mean interval of 11.7 months after the first (6.4+/-3.3 vs 3.5+/-1.2, p=0.042, respectively), while the chronicity index and the tubulointerstitial scores did not change. On the immunofluorescent findings at the second biopsies, the degree of deposits of immunoglobulins such as IgA, IgM, C3, and fibrinogen decreased in five of the six patients. Although this case series is without controls, our study suggests that CyA may be beneficial to a subset of HSN patients with nephrotic syndrome.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.