ArticleAmerican journal of respiratory cell and molecular biology2005
Allergic challenge-elicited lipid bodies compartmentalize in vivo leukotriene C4 synthesis within eosinophils.
Article in American journal of respiratory cell and molecular biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 56 citations in OpenAlex.
- A mechanism of benefit of soy genistein in asthma: inhibition of eosinophil p38-dependent leukotriene synthesis.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2008Trial
- IL-33 Elicits LTCEuropean journal of immunology · 2026Article
- Nonsteroidal anti-inflammatory drugs, blood metabolites, and kidney stones: a comprehensive Mendelian randomization study.Urolithiasis · 2025Article
- Photobiomodulation Reduces the Cytokine Storm Syndrome Associated with COVID-19 in the Zebrafish Model.International journal of molecular sciences · 2023Article
- Inflammasome-Independent Leukotriene BJournal of immunology (Baltimore, Md. : 1950) · 2018Article
- Lipid Droplet, a Key Player in Host-Parasite Interactions.Frontiers in immunology · 2018Review
- Lipid Bodies as Sites of Prostaglandin E2 Synthesis During Chagas Disease: Impact in the Parasite Escape Mechanism.Frontiers in microbiology · 2018Review
- EicosaCell: An Imaging-Based Assay to Identify Spatiotemporal Eicosanoid Synthesis.Methods in molecular biology (Clifton, N.J.) · 2017Article
- Rosmarinic Acid Attenuates Airway Inflammation and Hyperresponsiveness in a Murine Model of Asthma.Molecules (Basel, Switzerland) · 2016Article
- Lipid droplets in leukocytes: Organelles linked to inflammatory responses.Experimental cell research · 2016Review
- LEUKOCYTE LIPID BODIES - STRUCTURE AND FUNCTION AS "EICOSASOMES".Transactions of the American Clinical and Climatological Association · 2016Article
- Host Lipid Bodies as Platforms for Intracellular Survival of Protozoan Parasites.Frontiers in immunology · 2016Review
- Biology and pathobiology of lipid droplets and their potential role in the protection of the organ of Corti.Hearing research · 2015Review
- Anti-allergic properties of curine, a bisbenzylisoquinoline alkaloid.Molecules (Basel, Switzerland) · 2015Review
- Unraveling the complexity of lipid body organelles in human eosinophils.Journal of leukocyte biology · 2014Review
- The internal architecture of leukocyte lipid body organelles captured by three-dimensional electron microscopy tomography.PloS one · 2013Article
- Lipid body-phagosome interaction in macrophages during infectious diseases: host defense or pathogen survival strategy?PLoS pathogens · 2012Review
- Eosinophils as a novel cell source of prostaglandin D2: autocrine role in allergic inflammation.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Co-operative signalling through DP(1) and DP(2) prostanoid receptors is required to enhance leukotriene C(4) synthesis induced by prostaglandin D(2) in eosinophils.British journal of pharmacology · 2011Article
- Identifying intracellular sites of eicosanoid lipid mediator synthesis with EicosaCell assays.Methods in molecular biology (Clifton, N.J.) · 2011Review
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Eosinophils are an important source of leukotriene (LT)C(4), which can be synthesized within lipid bodies-cytoplasmic organelles where eicosanoid formation may take place. Allergy-driven lipid body formation and function have never been investigated. Here, we studied the in vivo induction and role of lipid bodies within eosinophils recruited to sites of allergic inflammation. Using two murine models of allergic inflammation (asthma and pleurisy), we verified that parallel to the eosinophil influx, allergic challenge also induced lipid body formation within recruited eosinophils. Neutralizing antibodies to eotaxin/CCL11, RANTES/CCL5, or CCR3 partially inhibited lipid body formation within recruited eosinophils in the allergic pleurisy model. Likewise, intrapleural administration of RANTES or eotaxin also induced significant influx of eosinophils loaded with lipid bodies. By immunolabeling, we detected the presence of a key enzyme involved in the leukotriene metabolism-5-lipoxygenase-within eosinophil lipid bodies formed in vivo after allergen challenge. Furthermore, specific immunolocalization of newly formed LTC(4) demonstrated that lipid bodies were the sites of formation of this eicosanoid within infiltrating eosinophils. Therefore, allergic inflammation triggers in vivo formation of new lipid bodies within infiltrating eosinophils, a phenomenon largely mediated by eotaxin/RANTES acting via CCR3 receptors. Such in vivo allergen-driven lipid bodies function as intracellular compartments of LTC(4) synthesis.
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