ArticleBMJ (Clinical research ed.)2005
Risk of myocardial infarction in patients taking cyclo-oxygenase-2 inhibitors or conventional non-steroidal anti-inflammatory drugs: population based nested case-control analysis.
Article in BMJ (Clinical research ed.), 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 137 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
137 citing papers in PubMed, 6 syntheses or guidelines pooled it, 561 citations in OpenAlex.
- Effects of cupping therapy on chronic musculoskeletal pain and collateral problems: a systematic review and meta-analysis.BMJ open · 2025Pooled it
- Risk of acute myocardial infarction with NSAIDs in real world use: bayesian meta-analysis of individual patient data.BMJ (Clinical research ed.) · 2017Pooled it
- Myocardial infarction and individual nonsteroidal anti-inflammatory drugs meta-analysis of observational studies.Pharmacoepidemiology and drug safety · 2013Pooled it
- Non-steroidal anti-inflammatory drugs and myocardial infarctions: comparative systematic review of evidence from observational studies and randomised controlled trials.Annals of the rheumatic diseases · 2007Pooled it
- Osteoarthritis of the knee.BMJ clinical evidence · 2007Pooled it
- Risk of acute myocardial infarction with nonselective non-steroidal anti-inflammatory drugs: a meta-analysis.Arthritis research & therapy · 2006Pooled it
- Endoscopic ulcer rates in healthy subjects associated with use of aspirin (81 mg q.d.) alone or coadministered with celecoxib or naproxen: a randomized, 1-week trial.Digestive diseases and sciences · 2008Trial
- Economic evaluation of a rehabilitation program integrating exercise, self-management, and active coping strategies for chronic knee pain.Arthritis and rheumatism · 2007Trial
- Clinical effectiveness of a rehabilitation program integrating exercise, self-management, and active coping strategies for chronic knee pain: a cluster randomized trial.Arthritis and rheumatism · 2007Trial
- [Analgesia in colon surgery. Can the use of NSAIDs reduce the opioid consumption following conventional and laparoscopic interventions?].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2006Trial
- Drugs in Development to Manage Acute Pain.Drugs · 2025Review
- Risk prediction of covid-19 related death or hospital admission in adults testing positive for SARS-CoV-2 infection during the omicron wave in England (QCOVID4): cohort study.BMJ (Clinical research ed.) · 2023Article
- Importance of Coagulation Factors as Critical Components of Premature Cardiovascular Disease in Familial Hypercholesterolemia.International journal of molecular sciences · 2022Review
- Application of Traditional Japanese Drug Jidabokuippo in a Modern Society.Frontiers in pharmacology · 2022Review
- Risk prediction of covid-19 related death and hospital admission in adults after covid-19 vaccination: national prospective cohort study.BMJ (Clinical research ed.) · 2021Article
- Risk of thrombocytopenia and thromboembolism after covid-19 vaccination and SARS-CoV-2 positive testing: self-controlled case series study.BMJ (Clinical research ed.) · 2021Article
- Nonsteroidal anti-inflammatory drugs prevent gastric cancer associated with the use of proton pump inhibitors afterJGH open : an open access journal of gastroenterology and hepatology · 2021Article
- Insightful Valorization of the Biological Activities of Pani Heloch Leaves through Experimental and Computer-Aided Mechanisms.Molecules (Basel, Switzerland) · 2020Article
- Article
- Primary care providers' awareness, knowledge, and practice with regard to cardiovascular risk in patients with rheumatoid arthritis : PCPs' awareness, knowledge, and practice with regard to CV risks in patients with RA.Clinical rheumatology · 2020Article
77 more citing papers are in PubMed but not listed here.
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo determine the comparative risk of myocardial infarction in patients taking cyclo-oxygenase-2 and other non-steroidal anti-inflammatory drugs (NSAIDs) in primary care between 2000 and 2004; to determine these risks in patients with and without pre-existing coronary heart disease and in those taking and not taking aspirin.
designNested case-control study.
setting367 general practices contributing to the UK QRESEARCH database and spread throughout every strategic health authority and health board in England, Wales, and Scotland. SUBJECTS: 9218 cases with a first ever diagnosis of myocardial infarction during the four year study period; 86 349 controls matched for age, calendar year, sex, and practice. OUTCOME MEASURES: Unadjusted and adjusted odds ratios with 95% confidence intervals for myocardial infarction associated with rofecoxib, celecoxib, naproxen, ibuprofen, diclofenac, and other selective and non-selective NSAIDS. Odds ratios were adjusted for smoking status, comorbidity, deprivation, and use of statins, aspirin, and antidepressants.
resultsA significantly increased risk of myocardial infarction was associated with current use of rofecoxib (adjusted odds ratio 1.32, 95% confidence interval 1.09 to 1.61) compared with no use within the previous three years; with current use of diclofenac (1.55, 1.39 to 1.72); and with current use of ibuprofen (1.24, 1.11 to 1.39). Increased risks were associated with the other selective NSAIDs, with naproxen, and with non-selective NSAIDs; these risks were significant at < 0.05 rather than < 0.01 for current use but significant at < 0.01 in the tests for trend. No significant interactions occurred between any of the NSAIDs and either aspirin or coronary heart disease.
conclusionThese results suggest an increased risk of myocardial infarction associated with current use of rofecoxib, diclofenac, and ibuprofen despite adjustment for many potential confounders. No evidence was found to support a reduction in risk of myocardial infarction associated with current use of naproxen. This is an observational study and may be subject to residual confounding that cannot be fully corrected for. However, enough concerns may exist to warrant a reconsideration of the cardiovascular safety of all NSAIDs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.