ArticleAmerican journal of respiratory and critical care medicine2005
Abnormalities in nitric oxide and its derivatives in lung cancer.
Article in American journal of respiratory and critical care medicine, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
51 citing papers in PubMed, 2 syntheses or guidelines pooled it, 129 citations in OpenAlex.
- Nitric oxide in occurrence, progress and therapy of lung Cancer: a systemic review and meta-analysis.BMC cancer · 2021Pooled it
- An official American Thoracic Society Statement: pulmonary hypertension phenotypes.American journal of respiratory and critical care medicine · 2014Guideline
- Novel Blood-Based Extracellular Vesicle-Derived Biomarkers in Small Cell Lung Cancer Identified via Proximity Extension Assay.Cancers · 2026Article
- Ensemble-learning-assisted exhaled gas disease analysis based on in-situ construction of MOF-derived MOMicrosystems & nanoengineering · 2026Article
- Targeting Oxidative and Nitrosative Stress: Mechanistic Insights and Therapeutic Strategies for Radiation-Induced Lung Injury.Journal of inflammation research · 2026Review
- Tumor Metastasis in the Microcirculation.Advances in experimental medicine and biology · 2026Review
- Evaluating the impact of radiotherapy on nitrosative stress and thiol/disulfide dynamics in patients with lung cancer.Scientific reports · 2025Article
- Role of nitric oxide, prostaglandins, thromboxanes and endothelins in lung cancer: An overview.World journal of clinical cases · 2025Review
- Unveiling the Cytotoxic and NO Inhibitory Potential of Heliotropium dolosum Extracts from Türkiye: A First Insight Into Its Phenolic Profile.Plant foods for human nutrition (Dordrecht, Netherlands) · 2025Article
- NO- and HNitric oxide : biology and chemistry · 2024Review
- Gasotransmitters in the tumor microenvironment: Impacts on cancer chemotherapy (Review).Molecular medicine reports · 2022Review
- Molecular mechanism of ethanol fermentation inhibition via protein tyrosine nitration of pyruvate decarboxylase by reactive nitrogen species in yeast.Scientific reports · 2022Article
- Measurement of Exhaled Nitric Oxide in 456 Lung Cancer Patients Using a Ringdown FENO Analyzer.Metabolites · 2021Article
- Review
- Nitric Oxide System and Bronchial Epithelium: More Than a Barrier.Frontiers in physiology · 2021Review
- Modulation of the PD-1/PD-L1 immune checkpoint axis during inflammation-associated lung tumorigenesis.Carcinogenesis · 2020Article
- Association between Metabolites and the Risk of Lung Cancer: A Systematic Literature Review and Meta-Analysis of Observational Studies.Metabolites · 2020Review
- Nitric oxide represses the proliferation of Caco-2 cells by inducing S-GInternational journal of physiology, pathophysiology and pharmacology · 2019Article
- The dichotomous role of HBiochemical pharmacology · 2018Review
- Distinctive profiles of tumor-infiltrating immune cells and association with intensity of infiltration in colorectal cancer.Oncology letters · 2018Article
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
Abstract
rationaleA cellular prooxidant state promotes cells to neoplastic growth, in part because of modification of proteins and their functions. Reactive nitrogen species formed from nitric oxide (NO) or its metabolites, can lead to protein tyrosine nitration, which is elevated in lung cancer.
objectiveTo determine the alteration in these NO derivatives and the role they may play in contributing to lung carcinogenesis.
methodsWe analyzed levels of NO, nitrite (NO2-), nitrate (NO3-), and the location of the protein nitration and identified the proteins that are modified. MEASUREMENTS AND MAIN
resultsAlthough exhaled NO and NO2- were increased, endothelial NO synthase or inducible NO synthase expression was similar in the tumor and tumor-free regions. However, immunohistochemistry showed that nitrotyrosine was increased in the tumor relative to non-tumor-bearing sections. We used proteomics to identify the modified proteins (two-dimensional polyacrylamide gel electrophoresis; mass spectrometry). Both the degree of nitration and the protein nitration profile were altered. We identified more than 25 nitrated proteins, including metabolic enzymes, structural proteins, and proteins involved in prevention of oxidative damage. Alterations of the biology of NO metabolites and nitration of proteins may contribute to the mutagenic processes and promote carcinogenesis.
conclusionsThis study provides evidence in favor of a role for reactive nitrogen and oxygen species in lung cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.