ArticleEukaryotic cell2005
Saccharomyces cerevisiae heat shock transcription factor regulates cell wall remodeling in response to heat shock.
Article in Eukaryotic cell, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 70 citations in OpenAlex.
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- Transcriptional noise adjusted for expression levels reveals genes with high transcriptional noise that are highly expressed, functionally related, and co-regulated in yeast.Current genetics · 2022Article
- Proteolysis Degree of Protein Corona Affect Ultrasound-Induced Sublethal Effects onFoods (Basel, Switzerland) · 2022Article
- Loss of tolerance to multiple environmental stresses due to limitation of structural diversity of complex sphingolipids.Molecular biology of the cell · 2022Article
- The cell wall and the response and tolerance to stresses of biotechnological relevance in yeasts.Frontiers in microbiology · 2022Review
- Proteomics of Two Thermotolerant Isolates ofJournal of fungi (Basel, Switzerland) · 2021Article
- The Heat Shock Transcription Factor HsfA Is Essential for Thermotolerance and Regulates Cell Wall Integrity inFrontiers in microbiology · 2021Article
- Integrins in disguise - mechanosensors inMicrobial cell (Graz, Austria) · 2019Review
- HSFA2 Functions in the Physiological Adaptation of Undifferentiated Plant Cells to Spaceflight.International journal of molecular sciences · 2019Article
- Pectin Methylesterases: Cell Wall Remodeling Proteins Are Required for Plant Response to Heat Stress.Frontiers in plant science · 2018Review
- Molecular mechanisms that distinguish TFIID housekeeping from regulatable SAGA promoters.The EMBO journal · 2017Article
- Heat shock protein 90 is required for sexual and asexual development, virulence, and heat shock response in Fusarium graminearum.Scientific reports · 2016Article
- Condition-specific genetic interaction maps reveal crosstalk between the cAMP/PKA and the HOG MAPK pathways in the activation of the general stress response.Molecular systems biology · 2015Article
- Modifying Yeast Tolerance to Inhibitory Conditions of Ethanol Production Processes.Frontiers in bioengineering and biotechnology · 2015Review
- Saccharomyces cerevisiae genes involved in survival of heat shock.G3 (Bethesda, Md.) · 2013Article
- Biology of the heat shock response and protein chaperones: budding yeast (Saccharomyces cerevisiae) as a model system.Microbiology and molecular biology reviews : MMBR · 2012Review
- Deciphering the transcriptional-regulatory network of flocculation in Schizosaccharomyces pombe.PLoS genetics · 2012Article
- Association of constitutive hyperphosphorylation of Hsf1p with a defective ethanol stress response in Saccharomyces cerevisiae sake yeast strains.Applied and environmental microbiology · 2012Article
- Cbk1 kinase and Bck2 control MAP kinase activation and inactivation during heat shock.Molecular biology of the cell · 2011Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The heat shock transcription factor Hsf1 of the yeast Saccharomyces cerevisiae regulates expression of genes encoding heat shock proteins and a variety of other proteins as well. To better understand the cellular roles of Hsf1, we screened multicopy suppressor genes of a temperature-sensitive hsf1 mutation. The RIM15 gene, encoding a protein kinase that is negatively regulated by the cyclic AMP-dependent protein kinase, was identified as a suppressor, but Rim15-regulated stress-responsive transcription factors, such as Msn2, Msn4, and Gis1, were unable to rescue the temperature-sensitive growth phenotype of the hsf1 mutant. Another class of suppressors encoded cell wall stress sensors, Wsc1, Wsc2, and Mid2, and the GDP/GTP exchange factor Rom2 that interacts with these cell wall sensors. Activation of a protein kinase, Pkc1, which is induced by these cell wall sensor proteins upon heat shock, but not activation of the Pkc1-regulated mitogen-activated protein kinase cascade, was necessary for the hsf1 suppression. Like Wsc-Pkc1 pathway mutants, hsf1 cells exhibited an osmotic remedial cell lysis phenotype at elevated temperatures. Several of the other suppressors were found to encode proteins functioning in cell wall organization. These results suggest that Hsf1 in concert with Pkc1 regulates cell wall remodeling in response to heat shock.
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