ArticleEukaryotic cell2005
A genome sequence survey shows that the pathogenic yeast Candida parapsilosis has a defective MTLa1 allele at its mating type locus.
Article in Eukaryotic cell, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 71 citations in OpenAlex.
- Genomic epidemiology and phylogenomics ofFrontiers in cellular and infection microbiology · 2026Article
- Genetic and environmental control of parasexual reproduction in the pathogenicMicrobiology and molecular biology reviews : MMBR · 2025Review
- Analysis of clinicalAntimicrobial agents and chemotherapy · 2024Article
- Analysis of clinicalbioRxiv : the preprint server for biology · 2023Article
- Genetic Diversity of Human Fungal Pathogens.Current clinical microbiology reports · 2023Article
- Transcriptome and proteome profiling reveals complex adaptations of Candida parapsilosis cells assimilating hydroxyaromatic carbon sources.PLoS genetics · 2022Article
- AJournal of fungi (Basel, Switzerland) · 2021Article
- Unconventional Cell Division Cycles from Marine-Derived Yeasts.Current biology : CB · 2019Article
- Candida parapsilosis: from Genes to the Bedside.Clinical microbiology reviews · 2019Review
- Hybridization and emergence of virulence in opportunistic human yeast pathogens.Yeast (Chichester, England) · 2018Article
- Evolutionary restoration of fertility in an interspecies hybrid yeast, by whole-genome duplication after a failed mating-type switch.PLoS biology · 2017Article
- Phylogenomic evolutionary surveys of subtilase superfamily genes in fungi.Scientific reports · 2017Article
- Multiple Origins of the Pathogenic Yeast Candida orthopsilosis by Separate Hybridizations between Two Parental Species.PLoS genetics · 2016Article
- Clade- and species-specific features of genome evolution in the Saccharomycetaceae.FEMS yeast research · 2015Article
- Comparative phenotypic analysis of the major fungal pathogens Candida parapsilosis and Candida albicans.PLoS pathogens · 2014Article
- Comparative genome analysis and gene finding in Candida species using CGOB.Molecular biology and evolution · 2013Article
- Unexpected genomic variability in clinical and environmental strains of the pathogenic yeast Candida parapsilosis.Genome biology and evolution · 2013Article
- Presence and functionality of mating type genes in the supposedly asexual filamentous fungus Aspergillus oryzae.Applied and environmental microbiology · 2012Article
- Discovery of a phenotypic switch regulating sexual mating in the opportunistic fungal pathogen Candida tropicalis.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Using RNA-seq to determine the transcriptional landscape and the hypoxic response of the pathogenic yeast Candida parapsilosis.BMC genomics · 2011Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Candida parapsilosis is responsible for ca. 15% of Candida infections and is of particular concern in neonates and surgical intensive care patients. The related species Candida albicans has recently been shown to possess a functional mating pathway. To analyze the analogous pathway in C. parapsilosis, we carried out a genome sequence survey of the type strain. We identified ca. 3,900 genes, with an average amino acid identity of 59% with C. albicans. Of these, 23 are predicted to be predominantly involved in mating. We identified a genomic locus homologous to the MTLa mating type locus of C. albicans, but the C. parapsilosis type strain has at least two internal stop codons in the MTLa1 open reading frame, and two predicted introns are not spliced. These stop codons were present in MTLa1 of all eight C. parapsilosis isolates tested. Furthermore, we found that all isolates of C. parapsilosis tested appear to contain only the MTLa idiomorph at the presumptive mating locus, unlike C. albicans and C. dubliniensis. MTLalpha sequences are present but at a different chromosomal location. It is therefore likely that all (or at least the majority) of C. parapsilosis isolates have a mating pathway that is either defective or substantially different from that of C. albicans.
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