ReviewImmunology2005
Close encounters of the monoamine kind: immune cells betray their nervous disposition.
Review in Immunology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01650311 (Investigating Serotonin Signalling in IBD Patients), which is not on this map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Investigating Serotonin Signalling in IBD Patients
Who cites it
30 citing papers in PubMed.
- Understanding immune system dysfunction and its context in mood disorders: psychoneuroimmunoendocrinology and clinical interventions.Military Medical Research · 2024Review
- Role of Serotonergic System in Regulating Brain Tumor-Associated Neuroinflammatory Responses.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Dopamine, Immunity, and Disease.Pharmacological reviews · 2023Review
- The Role of the Second Extracellular Loop of Norepinephrine Transporter, Neurotrophin-3 and Tropomyosin Receptor Kinase C in T Cells: A Peripheral Biomarker in the Etiology of Schizophrenia.International journal of molecular sciences · 2021Article
- Sudden infant death syndrome: Melatonin, serotonin, and CD34 factor as possible diagnostic markers and prophylactic targets.PloS one · 2021Article
- Pharmacokinetics-pharmacodynamics of sertraline as an antifungal in HIV-infected Ugandans with cryptococcal meningitis.Journal of pharmacokinetics and pharmacodynamics · 2019Article
- Activation of dopamine D1 receptor decreased NLRP3-mediated inflammation in intracerebral hemorrhage mice.Journal of neuroinflammation · 2018Article
- The implication of neuronimmunoendocrine (NIE) modulatory network in the pathophysiologic process of Parkinson's disease.Cellular and molecular life sciences : CMLS · 2017Review
- New Insights on Platelets and Platelet-Derived Microparticles in Systemic Lupus Erythematosus.Current rheumatology reports · 2017Review
- The Effects of Serotonin in Immune Cells.Frontiers in cardiovascular medicine · 2017Review
- Article
- Changes in serotonin transporter (5-HTT) gene expression in peripheral blood cells after MDMA intake.Psychopharmacology · 2015Article
- Distinct single cell signal transduction signatures in leukocyte subsets stimulated with khat extract, amphetamine-like cathinone, cathine or norephedrine.BMC pharmacology & toxicology · 2013Article
- Inflammatory vulnerability associated with the rh5-HTTLPR genotype in juvenile rhesus monkeys.Genes, brain, and behavior · 2013Article
- Serotonin uptake is largely mediated by platelets versus lymphocytes in peripheral blood cells.ACS chemical neuroscience · 2013Article
- A dialogue between the immune system and brain, spoken in the language of serotonin.ACS chemical neuroscience · 2013Review
- Neuroimmunological mechanism of pruritus in atopic dermatitis focused on the role of serotonin.Biomolecules & therapeutics · 2012Review
- Enhancing the anti-lymphoma potential of 3,4-methylenedioxymethamphetamine ('ecstasy') through iterative chemical redesign: mechanisms and pathways to cell death.Investigational new drugs · 2012Article
- Article
- Serotonin-mediated tuning of human helper T cell responsiveness to the chemokine CXCL12.PloS one · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Here we review the evidence for immune cells expressing multiple components of the serotonergic and dopaminergic systems that are more commonly associated with the central nervous system (CNS). We discuss where and how peripheral encounters with these biogenic monoamines occur and posit reasons as to why the immune system would wish to deploy these pathways. A full taxonomy of serotonergic and dopaminergic constituents and their workings in component cells of the immune system should facilitate the formulation of novel therapeutic approaches in diseases characterized by immune dysfunction and potentially provide a range of surrogate peripheral markers for registering and monitoring disturbances within the CNS.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.