ArticleProceedings of the National Academy of Sciences of the United States of America1992
cDNA cloning and functional activity of a glucocorticoid-regulated inflammatory cyclooxygenase.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 140 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
140 citing papers in PubMed, 1 synthesis or guideline pooled it, 830 citations in OpenAlex.
- Efficacy and Safety of Celecoxib Therapy in Osteoarthritis: A Meta-Analysis of Randomized Controlled Trials.Medicine · 2016Pooled it
- Reduced systemic bicyclo-prostaglandin-E2 and cyclooxygenase-2 gene expression are associated with inefficient erythropoiesis and enhanced uptake of monocytic hemozoin in children with severe malarial anemia.American journal of hematology · 2012Trial
- Trial
- The Differential Early Responses of Human Leukocytes to Influenza Virus and Respiratory Syncytial Virus.Pathogens (Basel, Switzerland) · 2025Article
- Dual therapy with corticosteroid ablates the beneficial effect of DP2 antagonism in chronic experimental asthma.Nature communications · 2024Article
- Sirtuin 6 ameliorates arthritis through modulating cyclic AMP-responsive element binding protein/CCN1/cyclooxygenase 2 pathway in osteoblasts.Journal of bone and mineral metabolism · 2023Article
- Regulation of Cyclooxygenase-2 Expression in Human T Cells by Glucocorticoid Receptor-Mediated Transrepression of Nuclear Factor of Activated T Cells.International journal of molecular sciences · 2022Article
- Eicosanoids in platelets and the effect of their modulation by aspirin in the cardiovascular system (and beyond).British journal of pharmacology · 2019Review
- Postnatal changes in constitutive cyclooxygenase‑2 expression in the mice hippocampus and its function in synaptic plasticity.Molecular medicine reports · 2019Article
- Flipping the cyclooxygenase (Journal of lipid research · 2018Article
- Genomic and lipidomic analyses differentiate the compensatory roles of two COX isoforms during systemic inflammation in mice.Journal of lipid research · 2018Article
- Synthesis, crystallographic characterization, molecular docking and biological activity of isoquinoline derivatives.Chemistry Central journal · 2017Article
- Differential usage of COX-1 and COX-2 in prostaglandin production by mast cells and basophils.Biochemistry and biophysics reports · 2017Article
- Article
- Aspirin Intolerance: Experimental Models for Bed-to-Bench.Current drug targets · 2016Review
- Resolvins attenuate inflammation and promote resolution in cigarette smoke-exposed human macrophages.American journal of physiology. Lung cellular and molecular physiology · 2015Article
- Are cyclooxygenase-2 and nitric oxide involved in the dyskinesia of Parkinson's disease induced by L-DOPA?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Article
- Estrogen alters baseline and inflammatory-induced cytokine levels independent from hypothalamic-pituitary-adrenal axis activity.Cytokine · 2015Article
- Loss of EP2 receptor subtype in colonic cells compromise epithelial barrier integrity by altering claudin-4.PloS one · 2014Article
- Suppressed circulating bicyclo-PGE2 levels and leukocyte COX-2 transcripts in children co-infected with P. falciparum malaria and HIV-1 or bacteremia.Biochemical and biophysical research communications · 2013Article
80 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The antiinflammatory glucocorticoids are potent inhibitors of cyclooxygenase, a key regulator of prostaglandin synthesis; yet, the mechanism(s) by which this occurs is not fully understood. We have cloned a 4.1-kilobase (kb) cDNA, distinct from the previously cloned cyclooxygenase (2.8 kb), that confers cyclooxygenase activity to transfected cells. The mRNA for this newly discovered cyclooxygenase is unique for its long 3' untranslated region containing many AUUUA repeats. Levels of the 4.1-kb cyclooxygenase mRNA are rapidly increased by serum or interleukin 1 beta in mouse fibroblasts and human monocytes, respectively, and decreased by glucocorticoids, whereas levels of the 2.8-kb cyclooxygenase mRNA do not change. Similar effects are seen in the presence of cycloheximide where the 4.1-kb, but not the 2.8-kb, mRNA is greatly superinduced. Thus, there are both constitutive (2.8 kb) and regulated (4.1 kb) cyclooxygenase species, the latter most likely being a major mediator of inflammation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.