ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2005
Effects of Bax gene deletion on muscle and motoneuron degeneration in a sexually dimorphic neuromuscular system.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- DNA methylation and demethylation shape sexual differentiation of neurochemical phenotype.Hormones and behavior · 2023Article
- Effects of sex and prenatal androgen manipulations on Onuf's nucleus of rhesus macaques.Hormones and behavior · 2018Article
- Neonatal Inhibition of DNA Methylation Alters Cell Phenotype in Sexually Dimorphic Regions of the Mouse Brain.Endocrinology · 2017Article
- Patterns of cell death in the perinatal mouse forebrain.The Journal of comparative neurology · 2017Article
- Cellular and molecular mechanisms of sexual differentiation in the mammalian nervous system.Frontiers in neuroendocrinology · 2016Review
- Sex differences in the brain: a whole body perspective.Biology of sex differences · 2015Review
- Turning sex inside-out: Peripheral contributions to sexual differentiation of the central nervous system.Biology of sex differences · 2012Article
- Effects of blocking developmental cell death on sexually dimorphic calbindin cell groups in the preoptic area and bed nucleus of the stria terminalis.Biology of sex differences · 2012Article
- Effects of Bax gene deletion on social behaviors and neural response to olfactory cues in mice.The European journal of neuroscience · 2011Article
- Cell death and sexual differentiation of behavior: worms, flies, and mammals.Current opinion in neurobiology · 2010Review
- Targeted overexpression of human alpha-synuclein in oligodendroglia induces lesions linked to MSA-like progressive autonomic failure.Experimental neurology · 2010Article
- Neuroprotective actions of androgens on motoneurons.Frontiers in neuroendocrinology · 2009Review
- The organizational hypothesis and final common pathways: Sexual differentiation of the spinal cord and peripheral nervous system.Hormones and behavior · 2009Review
- Control of cell number in the sexually dimorphic brain and spinal cord.Journal of neuroendocrinology · 2009Review
- Sex differences in NeuN- and androgen receptor-positive cells in the bed nucleus of the stria terminalis are due to Bax-dependent cell death.Neuroscience · 2009Article
- The role of cell death in sexually dimorphic muscle development: male-specific muscles are retained in female bax/bak knockout mice.Developmental neurobiology · 2008Article
- Sexual differentiation of vasopressin innervation of the brain: cell death versus phenotypic differentiation.Endocrinology · 2008Article
- The spinal nucleus of the bulbocavernosus: firsts in androgen-dependent neural sex differences.Hormones and behavior · 2008Review
- Neuromuscular development in the absence of programmed cell death: phenotypic alteration of motoneurons and muscle.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Glutamate uptake block triggers deadly rhythmic bursting of neonatal rat hypoglossal motoneurons.The Journal of physiology · 2006Article
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3 authors.
Funding
Abstract
Motoneurons in the spinal nucleus of the bulbocavernosus (SNB) and their target muscles in the perineum, bulbocavernosus (BC), and levator ani (LA) normally degenerate in female rodents. Death of the motoneurons and muscles can be prevented by androgen treatments around the time of birth. To identify the intracellular mechanisms underlying hormone-dependent survival of this neuromuscular system, we examined mice with a targeted disruption of the pro-death gene Bax. SNB motoneuron number was increased in female Bax-/- mice, whether measured using immunolabeling for a motoneuron-specific marker or retrograde labeling with the fluorescent tracer Fluoro-Gold. Based on retrograde tracing, the sex difference in SNB cell number is eliminated in Bax-/- mice. Thus, Bax is required for sexually dimorphic motoneuron death in the SNB, and motoneurons rescued by Bax deletion project their axons to the periphery. Mean soma size in the SNB of Bax-/- females is reduced, however, and there is a subpopulation of very small cells in the SNB of female knock-outs. In addition, the BC muscle was not identified in any female, regardless of Bax gene status. All females possessed a small LA muscle, and Bax deletion resulted in a tripling of LA fiber number in females. This increase was small, however, relative to the >50-fold sex difference in LA muscle fiber number. Thus, the sex difference in the perineal muscles is mostly unaffected by the absence of Bax protein, and SNB motoneuron number is dissociated from target muscle size in Bax-/- animals.
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