ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2005
Synaptic facilitation and behavioral dishabituation in Aplysia: dependence on release of Ca2+ from postsynaptic intracellular stores, postsynaptic exocytosis, and modulation of postsynaptic AMPA receptor efficacy.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed, 89 citations in OpenAlex.
- Article
- Quantitative description of the interactions among kinase cascades underlying long-term plasticity of Aplysia sensory neurons.Scientific reports · 2021Article
- Possible novel features of synaptic regulation during long-term facilitation inLearning & memory (Cold Spring Harbor, N.Y.) · 2021Article
- Postsynaptic effects ofLearning & memory (Cold Spring Harbor, N.Y.) · 2020Article
- Autocrine signaling by anProceedings of the National Academy of Sciences of the United States of America · 2018Article
- Anterograde and retrograde signaling by anProceedings of the National Academy of Sciences of the United States of America · 2018Article
- Phylogenetic analysis of ionotropic L-glutamate receptor genes in the Bilateria, with special notes on Aplysia californica.BMC evolutionary biology · 2017Article
- Article
- Nonassociative learning in invertebrates.Cold Spring Harbor perspectives in biology · 2015Review
- cJun and CREB2 in the postsynaptic neuron contribute to persistent long-term facilitation at a behaviorally relevant synapse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Homolog of protein kinase Mζ maintains context aversive memory and underlying long-term facilitation in terrestrial snail Helix.Frontiers in cellular neuroscience · 2015Article
- C. elegans positive olfactory associative memory is a molecularly conserved behavioral paradigm.Neurobiology of learning and memory · 2014Article
- Glutamatergic autoencephalitides: an emerging field.Journal of neural transmission (Vienna, Austria : 1996) · 2014Review
- Persistent long-term facilitation at an identified synapse becomes labile with activation of short-term heterosynaptic plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Mobility of acetylcholine receptors in command Helix lucorum neurons in a cellular analog of habituation.Invertebrate neuroscience : IN · 2013Article
- Cellular, molecular, and epigenetic mechanisms in non-associative conditioning: implications for pain and memory.Neurobiology of learning and memory · 2013Review
- Calcineurin-dependent cofilin activation and increased retrograde actin flow drive 5-HT-dependent neurite outgrowth in Aplysia bag cell neurons.Molecular biology of the cell · 2012Article
- Serotonin-induced cleavage of the atypical protein kinase C Apl III in Aplysia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Reconsolidation of long-term memory in Aplysia.Current biology : CB · 2012Article
- Mapping molecular memory: navigating the cellular pathways of learning.Cellular and molecular neurobiology · 2012Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Sensitization and dishabituation of the defensive withdrawal reflex in Aplysia have been ascribed to presynaptic mechanisms, particularly presynaptic facilitation of transmission at sensorimotor synapses in the CNS of Aplysia. Here, we show that facilitation of sensorimotor synapses in cell culture during and after serotonin (5-HT) exposure depends on a rise in postsynaptic intracellular Ca(2+) and release of Ca(2+) from postsynaptic stores. We also provide support for the idea that postsynaptic AMPA receptor insertion mediates a component of synaptic facilitation by showing that facilitation after 5-HT offset is blocked by injecting botulinum toxin, an exocytotic inhibitor, into motor neurons before application of 5-HT. Using a reduced preparation, we extend our results to synaptic facilitation in the abdominal ganglion. We show that tail nerve shock-induced facilitation of siphon sensorimotor synapses also depends on elevated postsynaptic Ca(2+) and release of Ca(2+) from postsynaptic stores and recruits a late phase of facilitation that involves selective enhancement of the AMPA receptor-mediated synaptic response. To examine the potential role of postsynaptic exocytosis of AMPA receptors in learning in Aplysia, we test the effect of injecting botulinum toxin into siphon motor neurons on dishabituation of the siphon-withdrawal reflex. We find that postsynaptic injections of the toxin block dishabituation resulting from tail shock. Our results indicate that postsynaptic mechanisms, particularly Ca(2+)-dependent modulation of AMPA receptor trafficking, play a critical role in synaptic facilitation as well as in dishabituation and sensitization in Aplysia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.