ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2005
Urotensin II modulates rapid eye movement sleep through activation of brainstem cholinergic neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 77 citations in OpenAlex.
- Molecular and functional profiling of cell diversity and identity in the lateral superior olive, an auditory brainstem center with ascending and descending projections.Frontiers in cellular neuroscience · 2024Article
- Neuroimmune interactions with binge alcohol drinking in the cerebellum of IL-6 transgenic mice.Neuropharmacology · 2023Article
- Role of astrocytes in sleep deprivation: accomplices, resisters, or bystanders?Frontiers in cellular neuroscience · 2023Review
- Zebrafish: an important model for understanding scoliosis.Cellular and molecular life sciences : CMLS · 2022Review
- Microinjection of urotensin II into the pedunculopontine tegmentum leads to an increase in the consumption of sweet tastants.Physiology & behavior · 2020Article
- Gating and the Need for Sleep: Dissociable Effects of Adenosine AFrontiers in neuroscience · 2019Review
- Altered brain activity during withdrawal from chronic alcohol is associated with changes in IL-6 signal transduction and GABAergic mechanisms in transgenic mice with increased astrocyte expression of IL-6.Neuropharmacology · 2018Article
- The Leptomeninges Produce Prostaglandin DFrontiers in cellular neuroscience · 2018Article
- A resource of potential drug targets and strategic decision-making for obstructive sleep apnoea pharmacotherapy.Respirology (Carlton, Vic.) · 2017Review
- Structural and functional considerations of the cholinergic brainstem.Journal of neural transmission (Vienna, Austria : 1996) · 2016Review
- Transgenic mice with increased astrocyte expression of IL-6 show altered effects of acute ethanol on synaptic function.Neuropharmacology · 2016Article
- Polygraphic Recording Procedure for Measuring Sleep in Mice.Journal of visualized experiments : JoVE · 2016Article
- Article
- Plasma urotensin-2 level and Thr21Met but not Ser89Asn polymorphisms of the urotensin-2 gene are associated with migraines.The journal of headache and pain · 2016Article
- The Neurobiology of Sleep and Wakefulness.The Psychiatric clinics of North America · 2015Review
- How useful is optogenetic activation in determining neuronal function within dynamic circuits?Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Urotensin-II receptor stimulation of cardiac L-type Ca2+ channels requires the βγ subunits of Gi/o-protein and phosphatidylinositol 3-kinase-dependent protein kinase C β1 isoform.The Journal of biological chemistry · 2015Article
- Evaluating the Evidence Surrounding Pontine Cholinergic Involvement in REM Sleep Generation.Frontiers in neurology · 2015Review
- Pharmacological targeting of the mammalian clock regulates sleep architecture and emotional behaviour.Nature communications · 2014Article
- Endogenous cholinergic input to the pontine REM sleep generator is not required for REM sleep to occur.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
Abstract
Urotensin II (UII) is a cyclic neuropeptide with strong vasoconstrictive activity in the peripheral vasculature. UII receptor mRNA is also expressed in the CNS, in particular in cholinergic neurons located in the mesopontine tegmental area, including the pedunculopontine tegmental (PPT) and lateral dorsal tegmental nuclei. This distribution suggests that the UII system is involved in functions regulated by acetylcholine, such as the sleep-wake cycle. Here, we tested the hypothesis that UII influences cholinergic PPT neuron activity and alters rapid eye movement (REM) sleep patterns in rats. Local administration of UII into the PPT nucleus increases REM sleep without inducing changes in the cortical blood flow. Intracerebroventricular injection of UII enhances both REM sleep and wakefulness and reduces slow-wave sleep 2. Intracerebroventricular, but not local, administration of UII increases cortical blood flow. Moreover, whole-cell recordings from rat-brain slices show that UII selectively excites cholinergic PPT neurons via an inward current and membrane depolarization that were accompanied by membrane conductance decreases. This effect does not depend on action potential generation or fast synaptic transmission because it persisted in the presence of TTX and antagonists of ionotropic glutamate, GABA, and glycine receptors. Collectively, these results suggest that UII plays a role in the regulation of REM sleep independently of its cerebrovascular actions by directly activating cholinergic brainstem neurons.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.