ArticleGenetics2005
Neutral evolution of the nonbinding region of the anthocyanin regulatory gene Ipmyb1 in Ipomoea.
Article in Genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 41 citations in OpenAlex.
- Pollination syndromes and the origins of floral traits.Annals of botany · 2023Review
- Pseudogenized Amelogenin Reveals Early Tooth Loss in True Toads (Anura: Bufonidae).Integrative and comparative biology · 2021Article
- Stability of petal color polymorphism: the significance of anthocyanin accumulation in photosynthetic tissues.BMC plant biology · 2019Article
- Anthocyanin mutants of Japanese and common morning glories exhibit normal proanthocyanidin accumulation in seed coats.Plant biotechnology (Tokyo, Japan) · 2018Article
- Diversifying selection of the anthocyanin biosynthetic downstream gene UFGT accelerates floral diversity of island Scutellaria species.BMC evolutionary biology · 2016Article
- Article
- Characterization of the cis elements in the proximal promoter regions of the anthocyanin pathway genes reveals a common regulatory logic that governs pathway regulation.Journal of experimental botany · 2015Article
- Positive selection and functional divergence of R2R3-MYB paralogous genes expressed in inflorescence buds of Scutellaria species (Labiatae).International journal of molecular sciences · 2015Article
- A valid strategy for precise identifications of transcription factor binding sites in combinatorial regulation using bioinformatic and experimental approaches.Plant methods · 2013Article
- Cloning and characterization of cold, salt and drought inducible C-repeat binding factor gene from a highly cold adapted ecotype of Lepidium latifolium L.Physiology and molecular biology of plants : an international journal of functional plant biology · 2013Article
- Article
- The genetic basis of a rare flower color polymorphism in Mimulus lewisii provides insight into the repeatability of evolution.PloS one · 2013Article
- Flower color as a model system for studies of plant evo-devo.Frontiers in plant science · 2013Article
- Morning glory as a powerful model in ecological genomics: tracing adaptation through both natural and artificial selection.Heredity · 2011Review
- Comparative analysis of vertebrate PEPT1 and PEPT2 genes.Genetica · 2010Article
- Cold-induced modulation and functional analyses of the DRE-binding transcription factor gene, GmDREB3, in soybean (Glycine max L.).Journal of experimental botany · 2009Article
- Variation in constraint versus positive selection as an explanation for evolutionary rate variation among anthocyanin genes.Journal of molecular evolution · 2008Article
- Isolation of a regulatory gene of anthocyanin biosynthesis in tuberous roots of purple-fleshed sweet potato.Plant physiology · 2007Article
- A small family of MYB-regulatory genes controls floral pigmentation intensity and patterning in the genus Antirrhinum.The Plant cell · 2006Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plant transcription factors often contain domains that evolve very rapidly. Although it has been suggested that this rapid evolution may contribute substantially to phenotypic differentiation among species, this suggestion has seldom been tested explicitly. We tested the validity of this hypothesis by examining the rapidly evolving non-DNA-binding region of an R2R3-myb transcription factor that regulates anthocyanin expression in flowers of the genus Ipomoea. We first provide evidence that the W locus in Ipomoea purpurea, which determines whether flowers will be pigmented or white, corresponds to a myb gene segregating in southeastern U.S. populations for one functional allele and one nonfunctional allele. While the binding domain exhibits substantial selective constraint, the nonbinding region evolves at an average K(a)/K(s) ratio of 0.74. This elevated rate of evolution is due to relaxed constraint rather than to increased levels of positive selection. Despite this relaxed constraint, however, approximately 20-25% of the codons, randomly distributed throughout the nonbinding region, are highly constrained, with the remainder evolving neutrally, indicating that the entire region performs important function(s). Our results provide little indication that rapid evolution in this regulatory gene is driven by natural selection or that it is responsible for floral-color differences among Ipomoea species.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.