ArticleGenetics2005
Genomic mapping of direct and correlated responses to long-term selection for rapid growth rate in mice.
Article in Genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Mapping novel QTL and fine mapping of previously identified QTL associated with glucose tolerance using the collaborative cross mice.Mammalian genome : official journal of the International Mammalian Genome Society · 2024Article
- Genetics of murine type 2 diabetes and comorbidities.Mammalian genome : official journal of the International Mammalian Genome Society · 2022Review
- 'Fat's chances': Loci for phenotypic dispersion in plasma leptin in mouse models of diabetes mellitus.PloS one · 2019Article
- A multi-megabase copy number gain causes maternal transmission ratio distortion on mouse chromosome 2.PLoS genetics · 2015Article
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- Article
- Inferring genetic architecture of complex traits using Bayesian integrative analysis of genome and transcriptome data.BMC genomics · 2012Article
- Epistatic Control of Mammary Cancer Susceptibility in Mice may Depend on the Dietary Environment.Hereditary genetics : current research · 2012Article
- Genetic diversity of microsatellite loci in hierarchically structured populations.Theoretical population biology · 2011Article
- Exercise, weight loss, and changes in body composition in mice: phenotypic relationships and genetic architecture.Physiological genomics · 2011Article
- Maternal manganese restriction increases susceptibility to high-fat diet-induced dyslipidemia and altered adipose function in WNIN male rat offspring.Experimental diabetes research · 2011Article
- Sex-, diet-, and cancer-dependent epistatic effects on complex traits in mice.Frontiers in genetics · 2011Article
- Genomic mapping of social behavior traits in a F2 cross derived from mice selectively bred for high aggression.BMC genetics · 2010Article
- A search for quantitative trait loci controlling within-individual variation of physical activity traits in mice.BMC genetics · 2010Article
- Dietary fat-dependent transcriptional architecture and copy number alterations associated with modifiers of mammary cancer metastasis.Clinical & experimental metastasis · 2010Article
- Multi-tissue coexpression networks reveal unexpected subnetworks associated with disease.Genome biology · 2009Article
- Genotype X diet interactions in mice predisposed to mammary cancer. I. Body weight and fat.Mammalian genome : official journal of the International Mammalian Genome Society · 2008Article
- Genotype X diet interactions in mice predisposed to mammary cancer: II. Tumors and metastasis.Mammalian genome : official journal of the International Mammalian Genome Society · 2008Article
- Genetic regulation of hypothalamic cocaine and amphetamine-regulated transcript (CART) in BxD inbred mice.Brain research · 2008Article
- Genome-wide isolation of growth and obesity QTL using mouse speed congenic strains.BMC genomics · 2006Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Understanding the genetic architecture of traits such as growth, body composition, and energy balance has become a primary focus for biomedical and agricultural research. The objective of this study was to map QTL in a large F(2) (n = 1181) population resulting from an intercross between the M16 and ICR lines of mice. The M16 line, developed by long-term selection for 3- to 6-week weight gain, is larger, heavier, fatter, hyperphagic, and diabetic relative to its randomly selected control line of ICR origin. The F(2) population was phenotyped for growth and energy intake at weekly intervals from 4 to 8 weeks of age and for body composition and plasma levels of insulin, leptin, TNFalpha, IL6, and glucose at 8 weeks and was genotyped for 80 microsatellite markers. Since the F(2) was a cross between a selection line and its unselected control, the QTL identified likely represent genes that contributed to direct and correlated responses to long-term selection for rapid growth rate. Across all traits measured, 95 QTL were identified, likely representing 19 unique regions on 13 chromosomes. Four chromosomes (2, 6, 11, and 17) harbored loci contributing disproportionately to selection response. Several QTL demonstrating differential regulation of regional adipose deposition and age-dependent regulation of growth and energy consumption were identified.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.