ArticleGenetics2005
Systematic segregation to mutant mitochondrial DNA and accompanying loss of mitochondrial DNA in human NT2 teratocarcinoma Cybrids.
Article in Genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed.
- 2-Deoxy-D-glucose couples mitochondrial DNA replication with mitochondrial fitness and promotes the selection of wild-type over mutant mitochondrial DNA.Nature communications · 2021Article
- Screen for mitochondrial DNA copy number maintenance genes reveals essential role for ATP synthase.Molecular systems biology · 2014Article
- Cytoplasmic hybrid (cybrid) cell lines as a practical model for mitochondriopathies.Redox biology · 2014Review
- Mitochondria and cancer: past, present, and future.BioMed research international · 2013Review
- Roles of Mitochondrial DNA Changes on Cancer Initiation and Progression.Cell biology : research & therapy · 2012Article
- Mitochondria and cell bioenergetics: increasingly recognized components and a possible etiologic cause of Alzheimer's disease.Antioxidants & redox signaling · 2012Review
- The awakening of an advanced malignant cancer: an insult to the mitochondrial genome.Biochimica et biophysica acta · 2012Review
- Does mitochondrial DNA play a role in Parkinson's disease? A review of cybrid and other supportive evidence.Antioxidants & redox signaling · 2012Review
- mtDNA lineage analysis of mouse L-cell lines reveals the accumulation of multiple mtDNA mutants and intermolecular recombination.Genes & development · 2012Article
- Non-random mtDNA segregation patterns indicate a metastable heteroplasmic segregation unit in m.3243A>G cybrid cells.PloS one · 2012Article
- The conserved translocase Tim17 prevents mitochondrial DNA loss.Human molecular genetics · 2009Article
- Mitochondrial regulation of cancer associated nuclear DNA methylation.Biochemical and biophysical research communications · 2007Article
- Single-cell A3243G mitochondrial DNA mutation load assays for segregation analysis.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2007Article
- Depletion of mitochondrial DNA in leucocytes harbouring the 3243A->G mtDNA mutation.Journal of medical genetics · 2007Article
- Regulation of mitochondrial DNA content and cancer.MitochondrionReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
In this study a well-characterized pathological mutation at nucleotide position 3243 of human mitochondrial DNA was introduced into human rho(0) teratocarcinoma (NT2) cells. In cloned and mixed populations of NT2 cells heteroplasmic for the mutation, mitotic segregation toward increasing levels of mutant mitochondrial DNA always occurred. Rapid segregation was frequently followed by complete loss of mitochondrial DNA. These findings support the idea that pathological mitochondrial DNA mutations are particularly deleterious in specific cell types, which can explain some of the tissue-specific aspects of mitochondrial DNA diseases. Moreover, these findings suggest that mitochondrial DNA depletion may be an important and widespread feature of mitochondrial DNA disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.