ArticleMolecular biology of the cell2005
Adhesion-dependent and contractile ring-independent equatorial furrowing during cytokinesis in mammalian cells.
Article in Molecular biology of the cell, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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53 citing papers in PubMed, 90 citations in OpenAlex.
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- Aurora B-dependent polarization of the cortical actomyosin network during mitotic exit.EMBO reports · 2021Article
- Cleavage-furrow formation without F-actin inProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Precise Tuning of Cortical Contractility Regulates Cell Shape during Cytokinesis.Cell reports · 2020Article
- How cortical waves drive fission of motile cells.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Review
- Crosslinking activity of non-muscle myosin II is not sufficient for embryonic cytokinesis inDevelopment (Cambridge, England) · 2019Article
- Meddling with myosin's mechanobiology in cancer.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Molecular form and function of the cytokinetic ring.Journal of cell science · 2019Review
- Network Contractility During Cytokinesis-from Molecular to Global Views.Biomolecules · 2019Review
- The balance between adhesion and contraction during cell division.Current opinion in cell biology · 2019Review
- Contractility kits promote assembly of the mechanoresponsive cytoskeletal network.Journal of cell science · 2019Article
- Comparative phosphoproteomic analysis reveals signaling networks regulating monopolar and bipolar cytokinesis.Scientific reports · 2018Article
- Recent advances in cytokinesis: understanding the molecular underpinnings.F1000Research · 2018Review
- A novel mode of cytokinesis without cell-substratum adhesion.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Myosin II-dependent contraction of the contractile ring drives equatorial furrowing during cytokinesis in animal cells. Nonetheless, myosin II-null cells of the cellular slime mold Dictyostelium divide efficiently when adhering to substrates by making use of polar traction forces. Here, we show that in the presence of 30 microM blebbistatin, a potent myosin II inhibitor, normal rat kidney (NRK) cells adhering to fibronectin-coated surfaces formed equatorial furrows and divided in a manner strikingly similar to myosin II-null Dictyostelium cells. Such blebbistatin-resistant cytokinesis was absent in partially detached NRK cells and was disrupted in adherent cells if the advance of their polar lamellipodia was disturbed by neighboring cells. Y-27632 (40 microM), which inhibits Rho-kinase, was similar to 30 microM blebbistatin in that it inhibited cytokinesis of partially detached NRK cells but only prolonged furrow ingression in attached cells. In the presence of 100 microM blebbistatin, most NRK cells that initiated anaphase formed tight furrows, although scission never occurred. Adherent HT1080 fibrosarcoma cells also formed equatorial furrows efficiently in the presence of 100 microM blebbistatin. These results provide direct evidence for adhesion-dependent, contractile ring-independent equatorial furrowing in mammalian cells and demonstrate the importance of substrate adhesion for cytokinesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.