ArticleMolecular biology of the cell2005
Differential in vivo binding dynamics of somatic and oocyte-specific linker histones in oocytes and during ES cell nuclear transfer.
Article in Molecular biology of the cell, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 48 citations in OpenAlex.
- The Oocyte-Specific Linker Histone H1FOO Is Not Essential for Mouse Oogenesis and Fertility.Cells · 2022Article
- Chromatin transitions triggered by LH density as epigenetic regulators of the genome.Nucleic acids research · 2022Article
- The embryonic linker histone dBigH1 alters the functional state of active chromatin.Nucleic acids research · 2020Article
- Gene-based analyses of the maternal genome implicate maternal effect genes as risk factors for conotruncal heart defects.PloS one · 2020Article
- Epigenetic changes in mammalian gametes throughout their lifetime: the four seasons metaphor.Chromosoma · 2019Review
- Oocyte-specific maternal Slbp2 is required for replication-dependent histone storage and early nuclear cleavage in zebrafish oogenesis and embryogenesis.RNA (New York, N.Y.) · 2018Article
- H1foo Has a Pivotal Role in Qualifying Induced Pluripotent Stem Cells.Stem cell reports · 2016Article
- Germline-specific H1 variants: the "sexy" linker histones.Chromosoma · 2016Review
- Role of H1 linker histones in mammalian development and stem cell differentiation.Biochimica et biophysica acta · 2016Review
- Maternal control of early embryogenesis in mammals.Reproduction, fertility, and development · 2015Review
- Maternal histone variants and their chaperones promote paternal genome activation and boost somatic cell reprogramming.BioEssays : news and reviews in molecular, cellular and developmental biology · 2015Review
- What is the role of histone H1 heterogeneity? A functional model emerges from a 50 year mystery.AIMS biophysics · 2015Article
- Identifying candidate oocyte reprogramming factors using cross-species global transcriptional analysis.Cellular reprogramming · 2013Article
- Delineating nuclear reprogramming.Protein & cell · 2012Review
- Profiling of linker histone variants in ovarian cancer.Frontiers in bioscience (Landmark edition) · 2012Review
- Article
- Oocyte-type linker histone B4 is required for transdifferentiation of somatic cells in vivo.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2010Article
- Nucleosome interaction surface of linker histone H1c is distinct from that of H1(0).The Journal of biological chemistry · 2010Article
- Characterization of somatic cell nuclear reprogramming by oocytes in which a linker histone is required for pluripotency gene reactivation.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Chromatin remodeling complexes interact dynamically with a glucocorticoid receptor-regulated promoter.Molecular biology of the cell · 2008Article
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
Abstract
The embryonic genome is formed by fusion of a maternal and a paternal genome. To accommodate the resulting diploid genome in the fertilized oocyte dramatic global genome reorganizations must occur. The higher order structure of chromatin in vivo is critically dependent on architectural chromatin proteins, with the family of linker histone proteins among the most critical structural determinants. Although somatic cells contain numerous linker histone variants, only one, H1FOO, is present in mouse oocytes. Upon fertilization H1FOO rapidly populates the introduced paternal genome and replaces sperm-specific histone-like proteins. The same dynamic replacement occurs upon introduction of a nucleus during somatic cell nuclear transfer. To understand the molecular basis of this dynamic histone replacement process, we compared the localization and binding dynamics of somatic H1 and oocyte-specific H1FOO and identified the molecular determinants of binding to either oocyte or somatic chromatin in living cells. We find that although both histones associate readily with chromatin in nuclei of somatic cells, only H1FOO is capable of correct chromatin association in the germinal vesicle stage oocyte nuclei. This specificity is generated by the N-terminal and globular domains of H1FOO. Measurement of in vivo binding properties of the H1 variants suggest that H1FOO binds chromatin more tightly than somatic linker histones. We provide evidence that both the binding properties of linker histones as well as additional, active processes contribute to the replacement of somatic histones with H1FOO during nuclear transfer. These results provide the first mechanistic insights into the crucial step of linker histone replacement as it occurs during fertilization and somatic cell nuclear transfer.
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