Trial reportJournal of neurology, neurosurgery, and psychiatry2005
The safety of antiepileptic drug withdrawal in patients with non-epileptic seizures.
Trial report in Journal of neurology, neurosurgery, and psychiatry, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Trial
- Utility and safety of epilepsy monitoring unit in an inpatient psychiatric setting in Japan.Epilepsy & behavior reports · 2025Article
- A Retrospective Study Reviewing Timing to Onset of Habitual Psychogenic Non-Epileptic Seizures in a Home Video Telemetry Cohort.Brain sciences · 2024Article
- Case report on psychogenic nonepileptic seizures: A series of unfortunate events.Clinical case reports · 2022Article
- Functional neurological disorder: new subtypes and shared mechanisms.The Lancet. Neurology · 2022Review
- Psychogenic nonepileptic seizures: clinical characteristics and outcome.Brain and behavior · 2022Article
- A practical review of functional neurological disorder (FND) for the general physician.Clinical medicine (London, England) · 2021Review
- Cognitive Behavioral Therapy (CBT) in Psychogenic Non-Epileptic Seizures (PNES): A Case Report and Literature Review.Behavioral sciences (Basel, Switzerland) · 2019Article
- Long-term video EEG monitoring for diagnosis of psychogenic nonepileptic seizures.Neuropsychiatric disease and treatment · 2014Review
- Dissociative seizures: a challenge for neurologists and psychotherapists.Deutsches Arzteblatt international · 2013Review
- Recent developments in our understanding of the semiology and treatment of psychogenic nonepileptic seizures.Current neurology and neuroscience reports · 2012Review
- Differentiating between nonepileptic and epileptic seizures.Nature reviews. Neurology · 2011Review
- Depression and symptoms affect quality of life in psychogenic nonepileptic seizures.Neurology · 2009Article
- Nonepileptic seizures treatment workshop summary.Epilepsy & behavior : E&B · 2006Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo determine whether withdrawal of anticonvulsant drugs (AED) can be carried out safely in patients with non-epileptic seizures (NES).
methodsProspective evaluation of safety and outcome in 78 patients with NES who satisfied a standardised set of criteria for excluding the diagnosis of coexisting or underlying epilepsy.
findingsThe patients were taking from one to three AED. Sixty four patients were withdrawn as outpatients, 14 as inpatients. Five patients stopped their drugs abruptly, and two had AED restarted and had to be withdrawn again. Otherwise all patients adhered to withdrawal schedules. A new type of attack in addition to NES was seen in three patients (complex partial seizures in all three cases). NES frequency declined in the group as a whole over the period of the study (follow up 6-12 months) in all individuals except for eight patients in whom there was a transient increase. Fourteen patients reported new physical symptoms after withdrawal; however, no serious adverse events were reported.
conclusionsWith appropriate diagnostic investigation and surveillance during follow up withdrawal of AED can be achieved safely in patients with NES.
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