ArticleBMC cell biology2005
Localization of plasma membrane t-SNAREs syntaxin 2 and 3 in intracellular compartments.
Article in BMC cell biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 25 citations in OpenAlex.
- Molecular rhythm alterations in prefrontal cortex and nucleus accumbens associated with opioid use disorder.Translational psychiatry · 2022Article
- DM1 Transgenic Mice Exhibit Abnormal Neurotransmitter Homeostasis and Synaptic Plasticity in Association with RNA Foci and Mis-Splicing in the Hippocampus.International journal of molecular sciences · 2022Article
- Human microsporidian pathogenJournal of cell science · 2021Article
- Syntaxin 2 promotes colorectal cancer growth by increasing the secretion of exosomes.Journal of Cancer · 2021Article
- Membrane proteomic analysis reveals the intestinal development is deteriorated by intrauterine growth restriction in piglets.Functional & integrative genomics · 2020Article
- Phosphorylation of SNAP-23 regulates its dynamic membrane association during mast cell exocytosis.Biology open · 2017Article
- Analytical Strategy to Prioritize Alzheimer's Disease Candidate Genes in Gene Regulatory Networks Using Public Expression Data.Journal of Alzheimer's disease : JAD · 2017Article
- The human submandibular gland: immunohistochemical analysis of SNAREs and cytoskeletal proteins.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2012Article
- Exercise contributes to the effects of DHA dietary supplementation by acting on membrane-related synaptic systems.Brain research · 2010Article
- Sdmg1 is a conserved transmembrane protein associated with germ cell sex determination and germline-soma interactions in mice.Development (Cambridge, England) · 2008Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMembrane fusion requires the formation of a complex between a vesicle protein (v-SNARE) and the target membrane proteins (t-SNAREs). Syntaxin 2 and 3 are t-SNAREs that, according to previous over-expression studies, are predominantly localized at the plasma membrane. In the present study we investigated localization of the endogenous syntaxin 2 and 3.
resultsEndogenous syntaxin 2 and 3 were found in NRK cells in intracellular vesicular structures in addition to regions of the plasma membrane. Treatment of these cells with N-ethylmaleimide (NEM), which is known to inactivate membrane fusion, caused syntaxin 3 to accumulate in the trans-Golgi network and syntaxin 2 in perinuclear membrane vesicles. Kinetic analysis in the presence of NEM indicated that this redistribution of syntaxin 2 and 3 takes place via actin containing structures.
conclusionOur data suggest that syntaxin 2 cycles between the plasma membrane and the perinuclear compartment whereas syntaxin 3 cycles between the plasma membrane and the trans-Golgi network. It is possible that this cycling has an important role in the regulation of t-SNARE function.
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