ArticleOral microbiology and immunology2005
Oral and vaginal epithelial cell anti-Candida activity is acid labile and does not require live epithelial cells.
Article in Oral microbiology and immunology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 31 citations in OpenAlex.
- Impaired neutrophil extracellular trap-forming capacity contributes to susceptibility to chronic vaginitis in a mouse model of vulvovaginal candidiasis.Infection and immunity · 2024Article
- Applying the Host-Microbe Damage Response Framework toJournal of fungi (Basel, Switzerland) · 2020Review
- Novel Mechanism behind the Immunopathogenesis of Vulvovaginal Candidiasis: "Neutrophil Anergy".Infection and immunity · 2018Review
- Article
- Cytokines in the host response to Candida vaginitis: Identifying a role for non-classical immune mediators, S100 alarmins.Cytokine · 2012Review
- Candida-host interactions in HIV disease: implications for oropharyngeal candidiasis.Advances in dental research · 2011Review
- Epithelial cell-derived S100 calcium-binding proteins as key mediators in the hallmark acute neutrophil response during Candida vaginitis.Infection and immunity · 2010Article
- Annexin-A1 identified as the oral epithelial cell anti-Candida effector moiety.Molecular oral microbiology · 2010Article
- Interactions of Candida albicans with epithelial cells.Cellular microbiology · 2010Review
- Cervical mucins carry alpha(1,2)fucosylated glycans that partly protect from experimental vaginal candidiasis.Glycoconjugate journal · 2009Article
- Immune defence mechanisms and immunoenhancement strategies in oropharyngeal candidiasis.Expert reviews in molecular medicine · 2008Review
- Candida-induced oral epithelial cell responses.Mycopathologia · 2006Article
- Role for dendritic cells in immunoregulation during experimental vaginal candidiasis.Infection and immunity · 2006Article
- Vaginal epithelial cell anti-Candida albicans activity is associated with protection against symptomatic vaginal candidiasis.Infection and immunity · 2005Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundCandida albicans is the causative agent of oral and vaginal candidiasis. Innate host defenses against C. albicans are important against each infection. Among these are oral and vaginal epithelial cells that have anti-Candida activity. The mechanism of action includes a requirement for cell contact with no role for soluble factors, and a putative role for carbohydrates based on the sensitivity of the activity to periodic acid.
methodsPeriodic acid treatment of epithelial cells as well as the property of partial resistance of antifungal activity to fixation was used to further dissect the mechanism of action.
resultsThe results herein effectively now challenge a role for carbohydrates alone. Firstly, the putative carbohydrate(s) released into supernatants of periodic acid-treated epithelial cells could not compete with fresh epithelial cells for activity, and equivalent abrogation of activity was observed by periodic acid-treated cells irrespective of the amount of carbohydrate released. Instead, the similar abrogation of activity following treatment with other acids or when cocultured under acidic conditions suggests that the activity is acid-labile. Finally, while activity requires intact epithelial cells, it does not require live cells; activity was minimally affected by fixing epithelial cells prior to coculture where the majority of cells remained impermeable to Trypan blue but were defined as non-viable by positive nuclear staining with propidium iodide.
conclusionThese results suggest that antifungal activity is dependent on contact by intact, but not necessarily live, epithelial cells through an acid-labile mechanism.
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