Trial reportExperimental brain research2005
Startle-induced reaction time shortening is not modified by prepulse inhibition.
Trial report in Experimental brain research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 67 citations in OpenAlex.
- Electroacupuncture for Motor Recovery in Subacute Stroke: A Randomized Trial Exploring CReST-Related Modulation.Brain and behavior · 2026Trial
- A block to pre-prepared movement in gait freezing, relieved by pedunculopontine nucleus stimulation.Brain : a journal of neurology · 2011Trial
- What Is the StartReact Effect?Acta physiologica (Oxford, England) · 2026Review
- Reticulospinal and corticospinal responses in long-term strength-trained and untrained adults.European journal of applied physiology · 2025Article
- The benefit of knowledge: postural response modulation by foreknowledge of equilibrium perturbation in an upper limb task.European journal of applied physiology · 2024Article
- Does the reticulospinal tract mediate adaptation to resistance training in humans?Journal of applied physiology (Bethesda, Md. : 1985) · 2022Review
- Startling stimuli increase maximal motor unit discharge rate and rate of force development in humans.Journal of neurophysiology · 2022Article
- Oddball onset timing: Little evidence of early gating of oddball stimuli from tapping, reacting, and producing.Attention, perception & psychophysics · 2021Article
- StartReact effects are dependent on engagement of startle reflex circuits: support for a subcortically mediated initiation pathway.Journal of neurophysiology · 2019Article
- Focus on the pedunculopontine nucleus. Consensus review from the May 2018 brainstem society meeting in Washington, DC, USA.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2019Review
- Mechanical perturbations can elicit triggered reactions in the absence of a startle response.Experimental brain research · 2018Article
- StartReact effects in first dorsal interosseous muscle are absent in a pinch task, but present when combined with elbow flexion.PloS one · 2018Article
- Reticulospinal Contributions to Gross Hand Function after Human Spinal Cord Injury.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Fractionation of muscle activity in rapid responses to startling cues.Journal of neurophysiology · 2017Article
- Foreknowledge of an impending startling stimulus does not affect the proportion of startle reflexes or latency of StartReact responses.Experimental brain research · 2017Article
- Go-activation endures following the presentation of a stop-signal: evidence from startle.Journal of neurophysiology · 2017Article
- Evidence for Startle Effects due to Externally Induced Lower Limb Movements: Implications in Neurorehabilitation.BioMed research international · 2017Article
- Article
- Reply to Maslovat et al.Journal of neurophysiology · 2015Article
- Responses to startling acoustic stimuli indicate that movement-related activation does not build up in anticipation of action.Journal of neurophysiology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A startling auditory stimulus delivered during preparation for execution of a ballistic movement in a simple reaction time task experiment induces two effects: a startle response and a reaction time shortening (the StartReact effect). We investigated whether prepulse inhibition of the startle response is effective in suppressing either one of these effects during motor preparation. Twelve healthy volunteers were presented with seven different experimental conditions in random order: while at rest, subjects received a low intensity electrical shock on the middle finger of the left hand (Prep), a loud auditory stimulus (Start), or a combination of these two (PrepStart). While engaged in preparation for a visual simple reaction time task, they were presented with the imperative signal for execution of the reaction (React), or with any of the combinations PrepReact, StartReact, or PrepStartReact. We recorded the EMG activity from the orbicularis oculi and the sternocleidomastoid muscles to assess the startle response, and from the wrist extensor muscles to assess reaction time. The startle response was markedly reduced when Prep was presented 100 ms before Start regardless of whether the subjects were at rest or preparing for the reaction. Reaction time shortened significantly in StartReact trials with respect to React trials, and the percentage shortening was not different in trials in which Prep preceded StartReact and inhibited the startle response. The fact that prepulse inhibition of the startle response is not accompanied by modification of the StartReact effect indicates that there are separate physiological mechanisms for the two effects, an observation that has implications for further understanding of the processes underlying motor preparation for a ballistic reaction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.