ReviewMolecular psychiatry2005
Genetic tests of biologic systems in affective disorders.
Review in Molecular psychiatry, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 32 citations in OpenAlex.
- Prediction of complex human diseases from pathway-focused candidate markers by joint estimation of marker effects: case of chronic fatigue syndrome.Human genomics · 2015Article
- Serotonin transporter-linked polymorphic region (5-HTTLPR) genotype is associated with cortisol responsivity to naloxone challenge.Psychopharmacology · 2012Article
- Common and specific liability to addiction: approaches to association studies of opioid addiction.Drug and alcohol dependence · 2012Review
- Genome-wide association study identifies genes that may contribute to risk for developing heroin addiction.Psychiatric genetics · 2010Article
- Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotype.Molecular psychiatry · 2010Article
- New findings in the genetics of major psychoses.Dialogues in clinical neuroscience · 2010Review
- Neurotransmission and bipolar disorder: a systematic family-based association study.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2008Article
- Clock genes may influence bipolar disorder susceptibility and dysfunctional circadian rhythm.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2008Article
- Emotion-induced retrograde amnesia is determined by a 5-HTT genetic polymorphism.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Association analysis of monoamine oxidase A gene and bipolar affective disorder in Han Chinese.Behavioral and brain functions : BBF · 2008Article
- Genotype patterns that contribute to increased risk for or protection from developing heroin addiction.Molecular psychiatry · 2008Article
- Bioinformatic analysis of human CNS-expressed ion channels as candidates for episodic nervous system disorders.Neurogenetics · 2007Article
- Genetics of suicide.Molecular psychiatry · 2006Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To liberate candidate gene analyses from criticisms of inexhaustiveness of examination of specific candidate genes, or incompleteness in the choice of candidate genes to study for specific neurobiological pathways, study of sizeable sets of genes pertinent to each putative pathophysiological pathway is required. For many years, genes have been tested in a 'one by one' manner for association with major affective disorders, primarily bipolar illness. However, it is conceivable that not individual genes but abnormalities in several genes within a system or in several neuronal, neural, or hormonal systems are implicated in the functional hypotheses for etiology of affective disorders. Compilation of candidate genes for entire pathways is a challenge, but can reasonably be carried out for the major affective disorders as discussed here. We present here five groupings of genes implicated by neuropharmacological and other evidence, which suggest 252 candidate genes worth examining. Inexhaustiveness of gene interrogation would apply to many studies in which only one polymorphism per gene is analyzed. In contrast to whole-genome association studies, a study of a limited number of candidate genes can readily exploit information on genomic sequence variations obtained from databases and/or resequencing, and has an advantage of not having the complication of an extremely stringent statistical criterion for association.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.