Trial reportInternational journal of colorectal disease2006
Appendectomy, tonsillectomy, and risk of inflammatory bowel disease: a case control study in Iran.
Trial report in International journal of colorectal disease, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Dietary, lifestyle, and environmental factors associated with ulcerative colitis: a systematic review and meta-analysis of observational studies.Frontiers in nutrition · 2026Pooled it
- Childhood appendectomy is linked with higher digestive, respiratory, and genitourinary disease risk but lower inflammatory bowel disease risk.Evolution, medicine, and public health · 2026Article
- Mendelian randomization analysis reveals causal relationship between tonsillectomy and irritable bowel syndrome.Frontiers in surgery · 2025Article
- What Are the Different Phenotypes of Inflammatory Bowel Disease in Asia?Gut and liver · 2022Review
- Appendectomy and risk for inflammatory bowel disease: effect of age and time post appendectomy - a cohort study.BMJ open gastroenterology · 2022Article
- Appendectomy in childhood-did it save my sibling from getting ulcerative colitis?International journal of colorectal disease · 2021Article
- Prior Appendectomy and the Onset and Course of Crohn's Disease in Chinese Patients.Gastroenterology research and practice · 2019Article
- Time trend analysis and demographic features of inflammatory bowel disease in Tehran.Gastroenterology and hepatology from bed to bench · 2015Article
- Epidemiology of inflammatory bowel diseases in iran and Asia; a mini review.Iranian journal of medical sciences · 2013Review
- Epidemiological and clinical characteristics of inflammatory bowel disease in patients from northwestern iran.Middle East journal of digestive diseases · 2013Article
- What can we learn from inflammatory bowel disease in developing countries?Current gastroenterology reports · 2013Article
- Epidemiological, Demographic, and Colonic Extension ofUlcerative Colitis in Iran: A Systematic Review.Middle East journal of digestive diseases · 2013Review
- Bone mineral density in Iranian patients with inflammatory bowel disease.International journal of colorectal disease · 2006Article
- Knowledge of disease and health information needs of the patients with inflammatory bowel disease in a developing country.International journal of colorectal disease · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is some controversy about the prevalence of appendectomy and tonsillectomy among patients with Crohn's disease and a lower rate of appendectomy among patients with ulcerative colitis (UC). The objective of this study was to elucidate the role of appendectomy and tonsillectomy in Iranian patients with inflammatory bowel disease (IBD). Three hundred and eighty-two consecutive cases of UC and 46 cases of CD were included. Age and sex-matched controls were randomly selected. A total of 382 controls for UC and 184 controls for CD were enrolled. A standard record concerning smoking habit, history of appendectomy and tonsillectomy, OCP, and NSAID use was completed. Logistic regression analysis was used to evaluate potential confounding variables. Twelve patients (3.1%) with UC reported a previous history of appendectomy compared with 30 controls (7.9%) (OR=0.38, 95%CI=0.19-0.76, P<0.004). Appendectomy was reported by five patients (10.9%) with CD compared with four controls (2.2%) (OR=5.49, 95%CI=1.41-21.34, P<0.02). The logistic regression analysis showed that appendectomy is a risk factor in CD but has a modest protective effect for development of UC. No association with tonsillectomy was found for either disease. A statistically significant protective effect for smoking in UC was found (OR=0.2, 95%CI=0.13-0.32, P<0.0001). We have found an inverse association between OCP and NSAID use with UC, but not CD (P<0.0001 and P<0.001, respectively). Appendectomy is protective in UC, but a risk factor in CD among Iranian population. Tonsillectomy was not associated with either UC or CD disease. UC, but not CD, is a disease of non-smokers. The inverse association between ulcerative colitis and OCP or NSAID in the Iranian population is noted.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.