ArticleJournal of neuro-oncology2005
Benign tumors from the human nervous system express high levels of survivin and are resistant to spontaneous and radiation-induced apoptosis.
Article in Journal of neuro-oncology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 21 citations in OpenAlex.
- Expression of p16 and Survivin in gliomas and their correlation with cell proliferation.Oncology letters · 2015Article
- Serum survivin increases in prolactinoma.Journal of clinical medicine research · 2015Article
- Craniopharyngioma: Survivin expression and ultrastructure.Oncology letters · 2015Article
- Survivin delta Ex3 overexpression in thyroid malignancies.PloS one · 2014Article
- Caspase-3 and survivin expression in primary atypical and malignant meningiomas.ISRN neuroscience · 2013Article
- Expression and clinical significance of Wnt players and survivin in pituitary tumours.Endocrine pathology · 2012Article
- ErbB/HER receptor activation and preclinical efficacy of lapatinib in vestibular schwannoma.Neuro-oncology · 2010Article
- The p16INK4a tumor suppressor controls p21WAF1 induction in response to ultraviolet light.Nucleic acids research · 2007Article
- Survivin expression in ganglioglioma.Journal of neuro-oncology · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Survivin, an inhibitor of apoptosis, is over-expressed in foetal tissues and human cancers, but it is almost undetectable in normal tissues. Here we have assessed the level of the survivin protein in some benign tumors of the nervous system: meningioma, schwannoma, low-grade ependymoma, pilocytic astrocytoma and pituitary adenoma. Using immuno-blot analysis we present evidence that these low-grade tumors are positive for survivin expression. In agreement, flow cytometrical analysis showed that both spontaneous and radiation-induced apoptosis levels are very low in these neoplasms. Using host cell reactivation assay we have also shown that these tumor cells are proficient in the repair of gamma-ray-induced DNA damage. However, they are deficient in the removal of ultraviolet (UV) light-induced DNA photolesions, especially the shwannoma- and the pituitary adenoma-derived cells. These results suggest that survivin overexpression may be an early event in the stepwise tumoregenesis and hence could be responsible for the onset as well as the growth advantage during tumoregenic progression of malignant as well as benign neoplasms.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.