ArticleBone marrow transplantation2005
Improved outcome of treatment-resistant high-risk Langerhans cell histiocytosis after allogeneic stem cell transplantation with reduced-intensity conditioning.
Article in Bone marrow transplantation, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 110 citations in OpenAlex.
- Langerhans cell histiocytosis (LCH): guidelines for diagnosis, clinical work-up, and treatment for patients till the age of 18 years.Pediatric blood & cancer · 2013Guideline
- Trial
- Advances in allogeneic hematopoietic stem cell transplantation for Langerhans cell histiocytosis in children.Frontiers in immunology · 2025Review
- Adult pulmonary Langerhans cell histiocytosis revealed by central diabetes insipidus: A case report and literature review.Molecular and clinical oncology · 2020Article
- Nationwide retrospective review of hematopoietic stem cell transplantation in children with refractory Langerhans cell histiocytosis.International journal of hematology · 2020Review
- Targeted inhibition of the MAPK pathway: emerging salvage option for progressive life-threatening multisystem LCH.Blood advances · 2017Article
- Insights into the pathogenesis of Langerhans cell histiocytosis: the development of targeted therapies.ImmunoTargets and therapy · 2016Review
- Successful treatment of adult Langerhans cell histiocytosis with intensified chemotherapy.International journal of hematology · 2015Article
- How I treat Langerhans cell histiocytosis.Blood · 2015Article
- Haematopoietic stem cell transplantation for refractory Langerhans cell histiocytosis: outcome by intensity of conditioning.British journal of haematology · 2015Article
- Treatment of relapsed/refractory langerhans cell histiocytosis: a single centre experience.Indian journal of pediatrics · 2014Article
- A Rare Disease in Adult: Langerhans Cell Histiocytosis.World journal of oncology · 2013Article
- Pathological consequence of misguided dendritic cell differentiation in histiocytic diseases.Advances in immunology · 2013Review
- Multisystem Langerhans cell histiocytosis in children: current treatment and future directions.Paediatric drugs · 2011Review
- Improved outcome of refractory Langerhans cell histiocytosis in children with hematopoietic stem cell transplantation in Japan.Bone marrow transplantation · 2010Article
- Langerhans cell histiocytosis.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2008Review
- The use of reduced-intensity stem cell transplantation in haemophagocytic lymphohistiocytosis and Langerhans cell histiocytosis.Bone marrow transplantation · 2008Review
- Successful outcome of Langerhans cell histiocytosis complicated by therapy-related myelodysplasia and acute myeloid leukemia: a case report.Cases journal · 2008Article
- The role of BMT in childhood histiocytoses.Bone marrow transplantation · 2008Article
- Reduced intensity conditioning and allogeneic stem cell transplantation in childhood malignant and nonmalignant diseases.Bone marrow transplantation · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Children with multisystem Langerhans cell histiocytosis (LCH) and risk organ involvement who fail to respond to conventional chemotherapy have an extremely poor prognosis. Myeloablative stem cell transplantation (SCT) as a possible salvage approach for these patients has been associated with a high risk of transplant-related mortality. Therefore, allogeneic stem cell transplantation following a reduced-intensity conditioning regimen (RIC-SCT) has recently been performed as an alternative salvage approach. We report on the experience with allogeneic RIC-SCT in nine pediatric high-risk LCH patients. Conditioning regimen included fludarabine in all patients, melphalan in eight patients, total lymphoid irradiation in six patients, total body irradiation in two, antithymocyte globulin in five, and Campath in four patients. RIC-SCT was well tolerated with regard to common procedure-related complications. Two patients died 50 and 69 days after RIC-SCT, respectively. Seven out of the nine patients survived and showed no signs of disease activity (including one with nonengraftment and full autologous hematopoietic recovery) after median follow-up of 390 days post-SCT. Based on this observation, we conclude that RIC-SCT is a feasible procedure with low transplant-related morbidity and mortality and a promising new salvage approach for high-risk LCH patients with resistant risk organ involvement.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.