ArticleBone marrow transplantation2005
A longitudinal prospective study of health-related quality of life in breast cancer patients following high-dose chemotherapy with autologous blood stem cell transplantation.
Article in Bone marrow transplantation, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 4 syntheses or guidelines pooled it, 61 citations in OpenAlex.
- The impact of age on health utility values for older women with early-stage breast cancer: a systematic review and meta-regression.Health and quality of life outcomes · 2022Pooled it
- A Systematic Literature Review of Health Utility Values in Breast Cancer.Medical decision making : an international journal of the Society for Medical Decision Making · 2022Pooled it
- Multigene assays and molecular markers in breast cancer: systematic review of health economic analyses.Breast cancer research and treatment · 2013Pooled it
- Ethical issues in autologous stem cell transplantation (ASCT) in advanced breast cancer: a systematic literature review.BMC medical ethics · 2011Pooled it
- Health-related quality of life in breast cancer measured with EQ-5D-5L.Journal of patient-reported outcomes · 2026Article
- Article
- Review
- Data on Utility in Cost-Utility Analyses of Genetic Screen-and-Treat Strategies for Breast and Ovarian Cancer.Cancers · 2021Article
- Multigene tests for breast cancer: the physician's perspective.Oncotarget · 2021Article
- A Meta-Regression Analysis of Utility Weights for Breast Cancer: The Power of Patients' Experience.International journal of environmental research and public health · 2020Article
- Cost effectiveness of Gene Expression Profiling in Patients with Early-Stage Breast Cancer in a Middle-Income Country, Turkey: Results of a Prospective Multicenter Study.European journal of breast health · 2019Article
- Local Therapy Decisional Regret in Older Women With Breast Cancer: A Population-Based Study.International journal of radiation oncology, biology, physics · 2019Article
- Investigating the temporal course, relevance and risk factors of fatigue over 5 years: a prospective study among patients receiving allogeneic HSCT.Bone marrow transplantation · 2017Article
- Article
- Quality of Life and Psychopathology in Adults Who Underwent Hematopoietic Stem Cell Transplantation (HSCT) in Childhood: A Qualitative and Quantitative Analysis.Frontiers in psychology · 2017Article
- Targeted drugs and Psycho-oncological intervention for breast cancer patients.Journal of negative results in biomedicine · 2016Review
- Cost-effectiveness analysis of prognostic gene expression signature-based stratification of early breast cancer patients.PharmacoEconomics · 2015Article
- Economic Impact of Gene Expression Profiling in Patients with Early-Stage Breast Cancer in France.PloS one · 2015Article
- A decision impact, decision conflict and economic assessment of routine Oncotype DX testing of 146 women with node-negative or pNImi, ER-positive breast cancer in the U.K.British journal of cancer · 2013Article
- Feasibility test of a UK-scalable electronic system for regular collection of patient-reported outcome measures and linkage with clinical cancer registry data: the electronic Patient-reported Outcomes from Cancer Survivors (ePOCS) system.BMC medical informatics and decision making · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This prospective longitudinal study examined both short- and long-term changes in health-related quality of life (HRQL) in 52 breast cancer patients with poor prognosis receiving high-dose chemotherapy (HDC) treatment with autologous blood stem cell transplantation (ASCT). HRQL was measured seven times from baseline to 2 years post enrollment with the Functional Living Index-Cancer (FLIC), the EuroQol (EQ-5D), and a quality of life visual analogue scale. The percentage of questionnaires returned at each assessment time ranged from 80 to 92%. All three measures showed a similar pattern of change, with HRQL decreasing following administration of HDC, and returning to baseline levels 8 weeks post HDC. A repeated-measures analysis of variance showed that the FLIC at 2 years was significantly better than baseline (P=<0.0001). Difficulty sleeping, headaches, and decreased sexual interest were the most common symptoms reported in the longer term. Our results have implications for early psychosocial intervention in the care of breast cancer patients with poor prognosis undergoing treatment with HDC and ASCT because such interventions can further improve the quality of their survival.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.