ArticleAmerican journal of respiratory and critical care medicine2005
Oligoclonal CD4+ T cells in the lungs of patients with severe emphysema.
Article in American journal of respiratory and critical care medicine, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 2 of them syntheses that pooled it.
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Who cites it
55 citing papers in PubMed, 2 syntheses or guidelines pooled it, 152 citations in OpenAlex.
- Effects of Vitamin D on Respiratory Function and Immune Status for Patients with Chronic Obstructive Pulmonary Disease (COPD): A Systematic Review and Meta-Analysis.Computational and mathematical methods in medicine · 2022Pooled it
- Integrative genomics identifies new genes associated with severe COPD and emphysema.Respiratory research · 2018Pooled it
- Natural and disease-specific autoantibodies in chronic obstructive pulmonary disease.Clinical and experimental immunology · 2015Trial
- Lung tissue T cells are activated in chronic obstructive pulmonary disease with non-small cell lung cancer patients.Scientific reports · 2025Article
- Lung NR3C1Communications biology · 2025Article
- The role of vasculature and angiogenesis in respiratory diseases.Angiogenesis · 2024Review
- COPD patients with high blood eosinophil counts exhibit a lower rate of omicron infection and milder post-infection symptoms.The clinical respiratory journal · 2024Article
- Association of T cell infiltration and morphological change of thymus gland with the aggravation of pulmonary emphysema in testosterone deficiency.Biochemistry and biophysics reports · 2023Article
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- The mechanistic role of neutrophil lymphocyte ratio perturbations in the leading non communicable lifestyle diseases.F1000Research · 2022Review
- Therapeutic benefits of recombinant alpha1-antitrypsin IgG1 Fc-fusion protein in experimental emphysema.Respiratory research · 2021Article
- Monocyte-derived dendritic cells link localized secretory IgA deficiency to adaptive immune activation in COPD.Mucosal immunology · 2021Article
- COVID-19, COPD, and AECOPD: Immunological, Epidemiological, and Clinical Aspects.Frontiers in medicine · 2020Review
- How Do Innate Immune Cells Contribute to Airway Remodeling in COPD Progression?International journal of chronic obstructive pulmonary disease · 2020Review
- Impact of one versus two doses of mesenchymal stromal cells on lung and cardiovascular repair in experimental emphysema.Stem cell research & therapy · 2018Article
- Anti-bacterial antibody and T cell responses in bronchiectasis are differentially associated with lung colonization and disease.Respiratory research · 2018Article
- Neutrophilic Inflammation in the Immune Responses of Chronic Obstructive Pulmonary Disease: Lessons from Animal Models.Journal of immunology research · 2017Review
- Induction of pulmonary antibodies against oxidized lipids in mice exposed to cigarette smoke.Respiratory research · 2016Article
- Microarray analysis of long non-coding RNAs in COPD lung tissue.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2015Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
rationaleWithin the lungs of patients with severe emphysema, inflammation continues despite smoking cessation. Foci of T lymphocytes in the small airways of patients with emphysema have been associated with disease severity. Whether these T cells play an important role in this continued inflammatory response is unknown.
objectiveThe aim of this study was to determine if T cells recruited to the lungs of subjects with severe emphysema contain oligoclonal T-cell populations, suggesting their accumulation in response to antigenic stimuli.
methodsLung T-cell receptor (TCR) Vbeta repertoire from eight patients with severe emphysema and six control subjects was evaluated at the time of tissue procurement (ex vivo) and after 2 weeks of culture with interleukin 2 (in vitro). Junctional region nucleotide sequencing of expanded TCR-Vbeta subsets was performed.
resultsNo significantly expanded TCR-Vbeta subsets were identified in ex vivo samples. However, T cells grew from all emphysema (n = 8) but from only one of the control lung samples (n = 6) when exposed to interleukin 2 (p = 0.0013). Within the cultured cells, seven major CD4-expressing TCR-Vbeta subset expansions were identified from five of the patients with emphysema. These expansions were composed of oligoclonal populations of T cells that had already been expanded in vivo.
conclusionSevere emphysema is associated with inflammation involving T lymphocytes that are composed of oligoclonal CD4+ T cells. These T cells are accumulating in the lung secondary to conventional antigenic stimulation and are likely involved in the persistent pulmonary inflammation characteristic of severe emphysema.
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Registered trials
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