ArticleJournal of bacteriology2005
Evolutionary changes of the flhDC flagellar master operon in Shigella strains.
Article in Journal of bacteriology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- Vibrio cholerae motility is associated with inter-animal transmission.Nature communications · 2025Article
- Virulence and Antibiotic Resistance of aEPEC/STECPathogens (Basel, Switzerland) · 2025Article
- The rapid evolution of flagellar ion selectivity in experimental populations ofScience advances · 2022Article
- Roles of the second messenger c-di-GMP in bacteria: Focusing on the topics of flagellar regulation and Vibrio spp.Genes to cells : devoted to molecular & cellular mechanisms · 2022Review
- Article
- Stand-Alone EAL Domain Proteins Form a Distinct Subclass of EAL Proteins Involved in Regulation of Cell Motility and Biofilm Formation in Enterobacteria.Journal of bacteriology · 2017Article
- Mutations That Stimulate flhDC Expression in Escherichia coli K-12.Journal of bacteriology · 2015Article
- Distinct mutations led to inactivation of type 1 fimbriae expression in Shigella spp.PloS one · 2015Article
- Chemoreceptor gene loss and acquisition via horizontal gene transfer in Escherichia coli.Journal of bacteriology · 2013Article
- Intra-specific diversity of Serratia marcescens in Anopheles mosquito midgut defines Plasmodium transmission capacity.Scientific reports · 2013Article
- Intergenic sequence comparison of Escherichia coli isolates reveals lifestyle adaptations but not host specificity.Applied and environmental microbiology · 2011Article
- Independent emergence of Yersinia ruckeri biotype 2 in the United States and Europe.Applied and environmental microbiology · 2011Article
- Article
- Molecular pathogenesis of Shigella spp.: controlling host cell signaling, invasion, and death by type III secretion.Clinical microbiology reviews · 2008Review
- Role of motility and the flhDC Operon in Escherichia coli MG1655 colonization of the mouse intestine.Infection and immunity · 2007Article
- Revisiting the molecular evolutionary history of Shigella spp.Journal of molecular evolution · 2007Article
- Reduced selection leads to accelerated gene loss in Shigella.Genome biology · 2007Article
- Co-evolution of transcription factors and their targets depends on mode of regulation.Genome biology · 2006Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Shigella strains are nonmotile. The master operon of flagellar synthesis, flhDC, was analyzed for genetic damage in 46 Shigella strains representing all known serotypes. In 11 strains (B1, B3, B6, B8, B10, B18, D5, F1B, D10, F3A, and F3C) the flhDC operon was completely deleted. PCR and sequence analysis of the flhDC region of the remaining 35 strains revealed many insertions or deletions associated with insertion sequences, and the majority of the strains were found to be defective in their flhDC genes. As these genes also play a role in regulation of non-flagellar genes, the loss may have other consequences or be driven by selection pressures other than those against flagellar motility. It has been suggested that Shigella strains fall mostly into three clusters within Escherichia coli, with five outlier strains, four of which are also within E. coli (G. M. Pupo, R. Lan, and P. R. Reeves, Proc. Natl. Acad. Sci. USA 97:10567-10572, 2000). The distribution of genetic changes in the flhDC region correlated very well with the three clusters and outlier strains found using housekeeping gene DNA sequences, enabling us to follow the sequence of mutational change in the flhDC locus. Two cluster 2 strains were found to have unique flhDC sequences, which are most probably due to recombination during the exchange of the adjacent O-antigen gene clusters.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.