ArticleJournal of bacteriology2005
Regulation of transcription in a reduced bacterial genome: nutrient-provisioning genes of the obligate symbiont Buchnera aphidicola.
Article in Journal of bacteriology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
81 citing papers in PubMed, 148 citations in OpenAlex.
- Article
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- How do host age and nutrition affect density regulation of obligate versus facultative bacterial symbionts? Insights from the tsetse fly.ISME communications · 2025Article
- Salinity-driven niche differentiation within the aquatic Luna-1 subcluster.ISME communications · 2025Article
- Host-specific co-evolution likely driven by diet in Buchnera aphidicola.BMC genomics · 2024Article
- Coordination of host and endosymbiont gene expression governs endosymbiont growth and elimination in the cereal weevil Sitophilus spp.Microbiome · 2023Article
- Article
- No Transcriptional Compensation for Extreme Gene Dosage Imbalance in Fragmented Bacterial Endosymbionts of Cicadas.Genome biology and evolution · 2023Article
- Single mutation makes Escherichia coli an insect mutualist.Nature microbiology · 2022Article
- Evolutionarily recent dual obligatory symbiosis among adelgids indicates a transition between fungus- and insect-associated lifestyles.The ISME journal · 2022Article
- Host's demand for essential amino acids is compensated by an extracellular bacterial symbiont in a hemipteran insect model.Frontiers in physiology · 2022Article
- Roles of Bacterial Symbionts in Transmission of Plant Virus by Hemipteran Vectors.Frontiers in microbiology · 2022Review
- Insect-host control of obligate, intracellular symbiont density.Proceedings. Biological sciences · 2021Article
- Triple RNA-Seq characterizes aphid gene expression in response to infection with unequally virulent strains of the endosymbiont Hamiltonella defensa.BMC genomics · 2021Article
- Host-Endosymbiont Genome Integration in a Deep-Sea Chemosymbiotic Clam.Molecular biology and evolution · 2021Article
- Article
- Enhanced Symbiotic Characteristics in Bacterial Genomes with the Disruption of rRNA Operon.Biology · 2020Article
- An endosymbiont's journey through metamorphosis of its insect host.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Spatial and morphological reorganization of endosymbiosis during metamorphosis accommodates adult metabolic requirements in a weevil.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
21 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Buchnera aphidicola, the obligate symbiont of aphids, has an extremely reduced genome, of which about 10% is devoted to the biosynthesis of essential amino acids needed by its hosts. Most regulatory genes for these pathways are absent, raising the question of whether and how transcription of these genes responds to the major shifts in dietary amino acid content encountered by aphids. Using full-genome microarrays for B. aphidicola of the host Schizaphis graminum, we examined transcriptome responses to changes in dietary amino acid content and then verified behavior of individual transcripts using quantitative reverse transcriptase PCR. The only gene showing a consistent and substantial (>twofold) response was metE, which underlies methionine biosynthesis and which is the only amino acid biosynthetic gene retaining its ancestral regulator (metR). In another aphid host, Acyrthosiphon pisum, B. aphidicola has no functional metR and shows no response in metE transcript levels to changes in amino acid concentrations. Thus, the only substantial transcriptional response involves the one gene for which an ancestral regulator is retained. This result parallels that from a previous study on heat stress, in which only the few genes retaining the global heat shock promoter showed responses in transcript abundance. The irreversible losses of transcriptional regulators constrain ability to alter gene expression in the context of environmental fluctuations affecting the symbiotic partners.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.