ArticleJournal of bacteriology2005
Catabolism of benzoate and phthalate in Rhodococcus sp. strain RHA1: redundancies and convergence.
Article in Journal of bacteriology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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Who cites it
56 citing papers in PubMed, 145 citations in OpenAlex.
- Horizontal Gene Transfer and Genome Rearrangements Shape Bacterial Adaptation for Bioremediation.Environmental microbiology · 2026Review
- Biological Degradation of Phthalates: From Bioremediation to Plastic Waste Valorization.ChemSusChem · 2026Review
- A Foundation for Advancing Studies of the Biodegradation of Polyethylene Surrogates by Environmental and Model Laboratory Microbes.Environmental microbiology reports · 2026Article
- Differential effect of monoterpenes and flavonoids on the transcription of aromatic ring-hydroxylating dioxygenase genes inMicrobial genomics · 2025Article
- Biodegradation of Phenol at High Initial Concentration byMicroorganisms · 2025Article
- A mycofactocin-associated dehydrogenase is essential for ethylene glycol metabolism by Rhodococcus jostii RHA1.Applied microbiology and biotechnology · 2024Article
- The catabolism of lignin-derivedApplied and environmental microbiology · 2024Article
- Coexistence of specialist and generalist species within mixed plastic derivative-utilizing microbial communities.Microbiome · 2023Article
- Biochemical and Multi-Omics Approaches To Obtain Molecular Insights into the Catabolism of the Plasticizer Benzyl Butyl Phthalate inMicrobiology spectrum · 2023Article
- Molecular evaluation of the metabolism of estrogenic di(2-ethylhexyl) phthalate in Mycolicibacterium sp.Microbial cell factories · 2023Article
- Insights into the physiological and genomic characterization of three bacterial isolates from a highly alkaline, terrestrial serpentinizing system.Frontiers in microbiology · 2023Article
- Comparative and pangenomic analysis of the genus Streptomyces.Scientific reports · 2022Article
- Bacterial catabolism of acetovanillone, a lignin-derived compound.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Mapping of the benzoate metabolism by human gut microbiome indicates food-derived metagenome evolution.Scientific reports · 2021Article
- Biotransformation of Cortisone withMolecules (Basel, Switzerland) · 2021Article
- Metabolic engineering of Rhodococcus jostii RHA1 for production of pyridine-dicarboxylic acids from lignin.Microbial cell factories · 2021Article
- Bacterial Transformation of Aromatic Monomers in Softwood Black Liquor.Frontiers in microbiology · 2021Article
- Statistical Optimisation of Phenol Degradation and Pathway Identification through Whole Genome Sequencing of the Cold-Adapted Antarctic Bacterium,International journal of molecular sciences · 2020Article
- Characterization of alkylguaiacol-degrading cytochromes P450 for the biocatalytic valorization of lignin.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Δ1-Dehydrogenation and C20 Reduction of Cortisone and Hydrocortisone Catalyzed byMolecules (Basel, Switzerland) · 2020Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genomic and proteomic approaches were used to investigate phthalate and benzoate catabolism in Rhodococcus sp. strain RHA1, a polychlorinated biphenyl-degrading actinomycete. Sequence analyses identified genes involved in the catabolism of benzoate (ben) and phthalate (pad), the uptake of phthalate (pat), and two branches of the beta-ketoadipate pathway (catRABC and pcaJIHGBLFR). The regulatory and structural ben genes are separated by genes encoding a cytochrome P450. The pad and pat genes are contained on a catabolic island that is duplicated on plasmids pRHL1 and pRHL2 and includes predicted terephthalate catabolic genes (tpa). Proteomic analyses demonstrated that the beta-ketoadipate pathway is functionally convergent. Specifically, the pad and pat gene products were only detected in phthalate-grown cells. Similarly, the ben and cat gene products were only detected in benzoate-grown cells. However, pca-encoded enzymes were present under both growth conditions. Activity assays for key enzymes confirmed these results. Disruption of pcaL, which encodes a fusion enzyme, abolished growth on phthalate. In contrast, after a lag phase, growth of the mutant on benzoate was similar to that of the wild type. Proteomic analyses revealed 20 proteins in the mutant that were not detected in wild-type cells during growth on benzoate, including a CatD homolog that apparently compensated for loss of PcaL. Analysis of completed bacterial genomes indicates that the convergent beta-ketoadipate pathway and some aspects of its genetic organization are characteristic of rhodococci and related actinomycetes. In contrast, the high redundancy of catabolic pathways and enzymes appears to be unique to RHA1 and may increase its potential to adapt to new carbon sources.
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