ArticleGenetics2005
Deep haplotype divergence and long-range linkage disequilibrium at xp21.1 provide evidence that humans descend from a structured ancestral population.
Article in Genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Our Tangled Family Tree: New Genomic Methods Offer Insight into the Legacy of Archaic Admixture.Genome biology and evolution · 2021Review
- Maximum Likelihood Estimation of Species Trees from Gene Trees in the Presence of Ancestral Population Structure.Genome biology and evolution · 2020Article
- Genetics and evidence for balancing selection of a sex-linked colour polymorphism in a songbird.Nature communications · 2019Article
- Consistency and inconsistency of consensus methods for inferring species trees from gene trees in the presence of ancestral population structure.Theoretical population biology · 2016Article
- Detecting hybridization using ancient DNA.Molecular ecology · 2016Review
- Model-based analyses of whole-genome data reveal a complex evolutionary history involving archaic introgression in Central African Pygmies.Genome research · 2016Article
- Ancient DNA and the rewriting of human history: be sparing with Occam's razor.Genome biology · 2016Review
- The impact of whole-genome sequencing on the reconstruction of human population history.Nature reviews. Genetics · 2014Review
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- Paleopopulation genetics.Annual review of genetics · 2012Review
- The date of interbreeding between Neandertals and modern humans.PLoS genetics · 2012Article
- Genetic evidence for archaic admixture in Africa.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- A population genetics study of the familial Mediterranean fever gene: evidence of balancing selection under an overdominance regime.Genes and immunity · 2009Article
- A complex selection signature at the human AVPR1B gene.BMC evolutionary biology · 2009Article
- Early modern human diversity suggests subdivided population structure and a complex out-of-Africa scenario.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- A history of recurrent positive selection at the toll-like receptor 5 in primates.Molecular biology and evolution · 2009Article
- Widespread balancing selection and pathogen-driven selection at blood group antigen genes.Genome research · 2009Article
- Genetic structure in African populations: implications for human demographic history.Cold Spring Harbor symposia on quantitative biology · 2009Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Fossil evidence links human ancestry with populations that evolved from modern gracile morphology in Africa 130,000-160,000 years ago. Yet fossils alone do not provide clear answers to the question of whether the ancestors of all modern Homo sapiens comprised a single African population or an amalgamation of distinct archaic populations. DNA sequence data have consistently supported a single-origin model in which anatomically modern Africans expanded and completely replaced all other archaic hominin populations. Aided by a novel experimental design, we present the first genetic evidence that statistically rejects the null hypothesis that our species descends from a single, historically panmictic population. In a global sample of 42 X chromosomes, two African individuals carry a lineage of noncoding 17.5-kb sequence that has survived for >1 million years without any clear traces of ongoing recombination with other lineages at this locus. These patterns of deep haplotype divergence and long-range linkage disequilibrium are best explained by a prolonged period of ancestral population subdivision followed by relatively recent interbreeding. This inference supports human evolution models that incorporate admixture between divergent African branches of the genus Homo.
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