ArticleJournal of medical genetics2005
Murine candidate bleomycin induced pulmonary fibrosis susceptibility genes identified by gene expression and sequence analysis of linkage regions.
Article in Journal of medical genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Long Noncoding RNAInternational journal of molecular sciences · 2021Article
- Dual Effect of Bleomycin on Histopathological Features of Lungs and Mediastinal Fat-Associated Lymphoid Clusters in an Autoimmune Disease Mouse Model.Frontiers in immunology · 2021Article
- Identification of Potential Pathogenic Super-Enhancers-Driven Genes in Pulmonary Fibrosis.Frontiers in genetics · 2021Article
- The contribution of animal models to understanding the role of the immune system in human idiopathic pulmonary fibrosis.Clinical & translational immunology · 2020Article
- Radiation, inflammation and the immune response in cancer.Mammalian genome : official journal of the International Mammalian Genome Society · 2018Review
- Fine mapping of the major bleomycin-induced pulmonary fibrosis susceptibility locus in mice.Mammalian genome : official journal of the International Mammalian Genome Society · 2018Article
- Epigenetic Regulation of Interleukin 6 by Histone Acetylation in Macrophages and Its Role in Paraquat-Induced Pulmonary Fibrosis.Frontiers in immunology · 2016Article
- The Role of Lymphocytes in Radiotherapy-Induced Adverse Late Effects in the Lung.Frontiers in immunology · 2016Review
- The role of mouse strain differences in the susceptibility to fibrosis: a systematic review.Fibrogenesis & tissue repair · 2013Article
- MicroRNA profiling implicates the insulin-like growth factor pathway in bleomycin-induced pulmonary fibrosis in mice.Fibrogenesis & tissue repair · 2013Article
- Comparison of bleomycin-induced pulmonary apoptosis between NMRI mice and C57BL/6 mice.Research in pharmaceutical sciences · 2013Article
- Positional cloning reveals strain-dependent expression of Trim16 to alter susceptibility to bleomycin-induced pulmonary fibrosis in mice.PLoS genetics · 2013Article
- miR-29 is a major regulator of genes associated with pulmonary fibrosis.American journal of respiratory cell and molecular biology · 2011Article
- Static and dynamic mechanics of the murine lung after intratracheal bleomycin.BMC pulmonary medicine · 2011Article
- A genetic variant near the PMAIP1/Noxa gene is associated with increased bleomycin sensitivity.Human molecular genetics · 2011Article
- The role of catalase in pulmonary fibrosis.Respiratory research · 2010Article
- Cholesterol 25-hydroxylase production by dendritic cells and macrophages is regulated by type I interferons.Journal of leukocyte biology · 2010Article
- Identification of novel susceptibility genes in ozone-induced inflammation in mice.The European respiratory journal · 2010Article
- Increased local expression of coagulation factor X contributes to the fibrotic response in human and murine lung injury.The Journal of clinical investigation · 2009Article
- Animal models of acute lung injury.American journal of physiology. Lung cellular and molecular physiology · 2008Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPulmonary fibrosis is a complex disease for which the predisposing genetic variants remain unknown. In a prior study, susceptibility to bleomycin induced pulmonary fibrosis was mapped to loci Blmpf1 and Blmpf2 on chromosomes 17 and 11, respectively, in a C57BL/6J (B6, susceptible) and C3Hf/KAM (C3H, resistant) mouse cross.
methodsHerein, the genetic basis of bleomycin induced pulmonary fibrosis was investigated in an approach combining gene expression and sequencing data with previously mapped linkage intervals.
resultsIn this study, gene expression analysis with microarrays revealed 1892 genes or ESTs (expressed sequence tags) to be differentially expressed between bleomycin treated B6 and C3H mice and 67 of these genetic elements map to Blmpf1 or Blmpf2. This group included genes involved in an oxidative stress response, in apoptosis, and in immune regulation. A comparison of the B6 and C3H sequence, for Blmpf1 and Blmpf2, made using the NCBI database and available C3H sequence, revealed approximately 35% of the genes in these regions contain non-synonymous coding sequence changes. An assessment of genotype/phenotype correlation among other inbred strains revealed 36% of these B6/C3H sequence variations predict for the known bleomycin induced fibrosis susceptibility of the DBA (susceptible) and A/J (resistant) mouse strains.
conclusionsCombining genomics approaches of differential gene expression and sequence variation potentially identifies approximately 5% the linked genes as fibrosis susceptibility candidate genes in this mouse cross.
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