ArticleThe EMBO journal2004
Transrepression by a liganded nuclear receptor via a bHLH activator through co-regulator switching.
Article in The EMBO journal, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 151 citations in OpenAlex.
- Interaction of Vitamin D with Peptide Hormones with Emphasis on Parathyroid Hormone, FGF23, and the Renin-Angiotensin-Aldosterone System.Nutrients · 2022Review
- IGFBP-3 Interacts with the Vitamin D Receptor in Insulin Signaling Associated with Obesity in Visceral Adipose Tissue.International journal of molecular sciences · 2017Article
- Antiproliferative Effects of 1α-OH-vitDScientific reports · 2017Article
- Vitamin D and colorectal cancer: molecular, epidemiological and clinical evidence.The British journal of nutrition · 2016Review
- Mechanistic Effects of Calcitriol in Cancer Biology.Nutrients · 2015Review
- MDM2 binds and inhibits vitamin D receptor.Cell cycle (Georgetown, Tex.) · 2015Article
- Fundamentals of vitamin D hormone-regulated gene expression.The Journal of steroid biochemistry and molecular biology · 2014Review
- Genomic determinants of gene regulation by 1,25-dihydroxyvitamin D3 during osteoblast-lineage cell differentiation.The Journal of biological chemistry · 2014Article
- Nuclear receptors and epigenetic regulation: opportunities for nutritional targeting and disease prevention.Advances in nutrition (Bethesda, Md.) · 2014Review
- Genomic binding sites and biological effects of the vitamin D--VDR complex in multiple sclerosis [corrected].Neuromolecular medicine · 2014Review
- Inhibition of Methicillin-resistant Staphylococcus aureus-induced cytokines mRNA production in human bone marrow derived mesenchymal stem cells by 1,25-dihydroxyvitamin D3.BMC cell biology · 2014Article
- Vitamin D represses dentin matrix protein 1 in cementoblasts and osteocytes.Journal of dental research · 2014Article
- Vitamin D and the epigenome.Frontiers in physiology · 2014Review
- Vitamin D receptor inhibits nuclear factor κB activation by interacting with IκB kinase β protein.The Journal of biological chemistry · 2013Article
- Equivalent anticancer activities of dietary vitamin D and calcitriol in an animal model of breast cancer: importance of mammary CYP27B1 for treatment and prevention.The Journal of steroid biochemistry and molecular biology · 2013Review
- Nuclear receptors in bone physiology and diseases.Physiological reviews · 2013Review
- Vitamin D receptor signaling mechanisms: integrated actions of a well-defined transcription factor.Steroids · 2013Review
- HNF4α antagonists discovered by a high-throughput screen for modulators of the human insulin promoter.Chemistry & biology · 2012Article
- Dietary vitamin D₃ and 1,25-dihydroxyvitamin D₃ (calcitriol) exhibit equivalent anticancer activity in mouse xenograft models of breast and prostate cancer.Endocrinology · 2012Article
- Vitamin D resistance and colon cancer prevention.Carcinogenesis · 2012Review
Corrections and comments
- Retraction · 2014-12-01Concerns/Issues about Data · Duplication of/in Image · Investigation by Company/Institution · Investigation by Journal/Publisher ·
- Retracted
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vitamin D receptor (VDR) is essential for ligand-induced gene repression of 25(OH)D3 1alpha-hydroxylase (1alpha(OH)ase) in mammalian kidney, while this gene expression is activated by protein kinase A (PKA) signaling downstream of the parathyroid hormone action. The mapped negative vitamin D response element (1alphanVDRE) in the human 1alpha(OH)ase gene promoter (around 530 bp) was distinct from those of the reported DR3-like nVDREs, composed of two E-box-like motifs. Unlike the reported nVDREs, no direct binding of VDR/RXR heterodimer to 1alphanVDRE was detected. A bHLH-type factor, designated VDIR, was identified as a direct sequence-specific activator of 1nVDRE. The transactivation function of VDIR was further potentiated by activated-PKA signaling through phosphorylation of serine residues in the transactivation domains, with the recruitment of a p300 histone acetyltransferase co-activator. The ligand-dependent association of VDR/RXR heterodimer with VDIR bound to 1alphanVDRE caused the dissociation of p300 co-activators from VDIR, and the association of HDAC co-repressor complex components resulting in ligand-induced transrepression. Thus, the present study deciphers a novel mechanism of ligand-induced transrepression by nuclear receptor via co-regulator switching.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.