ArticleNucleic acids research2005
Covalent ligation studies on the human telomere quadruplex.
Article in Nucleic acids research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 70 citations in OpenAlex.
- G-Quadruplex-Forming Aptamers-Characteristics, Applications, and Perspectives.Molecules (Basel, Switzerland) · 2019Review
- Binding of BRACO19 to a Telomeric G-Quadruplex DNA Probed by All-Atom Molecular Dynamics Simulations with Explicit Solvent.Molecules (Basel, Switzerland) · 2019Article
- Multicharged Phthalocyanines as Selective Ligands for G-Quadruplex DNA Structures.Molecules (Basel, Switzerland) · 2019Article
- Polyethylene glycol binding alters human telomere G-quadruplex structure by conformational selection.Nucleic acids research · 2013Article
- Polymorphism of human telomeric quadruplex structure controlled by DNA concentration: a Raman study.Nucleic acids research · 2013Article
- Stability and free energy calculation of LNA modified quadruplex: a molecular dynamics study.Journal of computer-aided molecular design · 2012Article
- Structure and stability of a dimeric g-quadruplex formed by cyclic oligonucleotides.Journal of nucleic acids · 2010Article
- Single-molecule TPM studies on the conversion of human telomeric DNA.Biophysical journal · 2010Article
- Arrangements of human telomere DNA quadruplex in physiologically relevant K+ solutions.Nucleic acids research · 2009Article
- Sequence variant (CTAGGG)n in the human telomere favors a G-quadruplex structure containing a G.C.G.C tetrad.Nucleic acids research · 2009Article
- Reconstitution of uracil DNA glycosylase-initiated base excision repair in herpes simplex virus-1.The Journal of biological chemistry · 2009Article
- Dramatic effect of single-base mutation on the conformational dynamics of human telomeric G-quadruplex.Nucleic acids research · 2009Article
- Structure of the human telomere in K+ solution: a stable basket-type G-quadruplex with only two G-tetrad layers.Journal of the American Chemical Society · 2009Article
- Polymorphism of human telomeric quadruplex structures.Biochimie · 2008Review
- Structural polymorphism of intramolecular quadruplex of human telomeric DNA: effect of cations, quadruplex-binding drugs and flanking sequences.Nucleic acids research · 2008Article
- Structure of two intramolecular G-quadruplexes formed by natural human telomere sequences in K+ solution.Nucleic acids research · 2007Article
- Structure of the intramolecular human telomeric G-quadruplex in potassium solution: a novel adenine triple formation.Nucleic acids research · 2007Article
- Structure of the Hybrid-2 type intramolecular human telomeric G-quadruplex in K+ solution: insights into structure polymorphism of the human telomeric sequence.Nucleic acids research · 2007Article
- Investigation of spectral conversion of d(TTAGGG)4 and d(TTAGGG)13 upon potassium titration by a G-quadruplex recognizer BMVC molecule.Nucleic acids research · 2007Article
- Structure of the human telomere in K+ solution: an intramolecular (3 + 1) G-quadruplex scaffold.Journal of the American Chemical Society · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Recent X-ray crystallographic studies on the human telomere sequence d[AGGG(TTAGGG)3] revealed a unimolecular, parallel quadruplex structure in the presence of potassium ions, while earlier NMR results in the presence of sodium ions indicated a unimolecular, antiparallel quadruplex. In an effort to identify and isolate the parallel form in solution, we have successfully ligated into circular products the single-stranded human telomere and several modified human telomere sequences in potassium-containing solutions. Using these sequences with one or two terminal phosphates, we have made chemically ligated products via creation of an additional loop. Circular products have been identified by polyacrylamide gel electrophoresis, enzymatic digestion with exonuclease VII and electrospray mass spectrometry in negative ion mode. Optimum pH for the ligation reaction of the human telomere sequence ranges from 4.5 to 6.0. Several buffers were also examined, with MES yielding the greatest ligation efficiency. Human telomere sequences with two phosphate groups, one each at the 3' and 5' ends, were more efficient at ligation, via pyrophosphate bond formation, than the corresponding sequences with only one phosphate group, at the 5' end. Circular dichroism spectra showed that the ligation product was derived from an antiparallel, single-stranded guanine quadruplex rather than a parallel single-stranded guanine quadruplex structure.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.