ArticleApplied and environmental microbiology2005
Inhibition of efflux transporter-mediated fungicide resistance in Pyrenophora tritici-repentis by a derivative of 4'-hydroxyflavone and enhancement of fungicide activity.
Article in Applied and environmental microbiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Confrontations betweenApplied and environmental microbiology · 2026Article
- Cross-resistance inApplied and environmental microbiology · 2025Article
- Exploring the Potential Mechanism of Prothioconazole Resistance inJournal of fungi (Basel, Switzerland) · 2023Article
- Ascochyta blight in North Dakota field pea: the pathogen complex and its fungicide sensitivity.Frontiers in plant science · 2023Article
- The Synthesis, Fungicidal Activity, and in Silico Study of Alkoxy Analogues of Natural Precocenes I, II, and III.Molecules (Basel, Switzerland) · 2022Article
- The AbcCl1 transporter of Colletotrichum lindemuthianum acts as a virulence factor involved in fungal detoxification during common bean (Phaseolus vulgaris) infection.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2022Article
- Molecular Characterization of Laboratory Mutants ofJournal of fungi (Basel, Switzerland) · 2021Article
- Disarming the Host: Detoxification of Plant Defense Compounds During Fungal Necrotrophy.Frontiers in plant science · 2021Review
- Constraining Evolution ofFrontiers in microbiology · 2019Article
- Selection Pressure Pathways and Mechanisms of Resistance to the Demethylation Inhibitor-Difenoconazole inFrontiers in microbiology · 2018Article
- Apyrase inhibitors enhance the ability of diverse fungicides to inhibit the growth of different plant-pathogenic fungi.Molecular plant pathology · 2017Article
- Function of the genetic element 'Mona' associated with fungicide resistance in Monilinia fructicola.Molecular plant pathology · 2017Article
- Co-Occurrence of Two Allelic Variants of CYP51 in Erysiphe necator and Their Correlation with Over-Expression for DMI Resistance.PloS one · 2016Article
- Fitness is Recovered with the Decline of Dimethachlon Resistance in Laboratory-induced Mutants of Sclerotinia sclerotiorum after Long-term Cold Storage.The plant pathology journal · 2015Article
- Characterization and potential evolutionary impact of transposable elements in the genome of Cochliobolus heterostrophus.BMC genomics · 2014Article
- Structural basis of resistance to anti-cytochrome bc₁ complex inhibitors: implication for drug improvement.Current pharmaceutical design · 2014Review
- Exploitation of genomics in fungicide research: current status and future perspectives.Molecular plant pathology · 2013Review
- De novo transcriptome sequencing and analysis for Venturia inaequalis, the devastating apple scab pathogen.PloS one · 2013Article
- Abundance, distribution and potential impact of transposable elements in the genome of Mycosphaerella fijiensis.BMC genomics · 2012Article
- Xenobiotic efflux in bacteria and fungi: a genomics update.Advances in enzymology and related areas of molecular biology · 2011Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Populations of the causal agent of wheat tan spot, Pyrenophora tritici-repentis, that are collected from fields frequently treated with reduced fungicide concentrations have reduced sensitivity to strobilurin fungicides and azole fungicides (C14-demethylase inhibitors). Energy-dependent efflux transporter activity can be induced under field conditions and after in vitro application of sublethal amounts of fungicides. Efflux transporters can mediate cross-resistance to a number of fungicides that belong to different chemical classes and have different modes of action. Resistant isolates can grow on substrata amended with fungicides and can infect plants treated with fungicides at levels above recommended field concentrations. We identified the hydroxyflavone derivative 2-(4-ethoxy-phenyl)-chromen-4-one as a potent inhibitor of energy-dependent fungicide efflux transporters in P. tritici-repentis. Application of this compound in combination with fungicides shifted fungicide-resistant P. tritici-repentis isolates back to normal sensitivity levels and prevented infection of wheat leaves. These results highlight the role of energy-dependent efflux transporters in fungicide resistance and could enable a novel disease management strategy based on the inhibition of fungicide efflux to be developed.
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