ArticleApplied and environmental microbiology2005
Indications for acquisition of reductive dehalogenase genes through horizontal gene transfer by Dehalococcoides ethenogenes strain 195.
Article in Applied and environmental microbiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 42 citations in OpenAlex.
- Halogenation and Dehalogenation Potential of Microorganisms in Yangtze River Waters.Microorganisms · 2025Article
- Pangenomic insights intoMicrobial genomics · 2024Article
- Structure of a membrane-bound menaquinol:organohalide oxidoreductase.Nature communications · 2023Article
- Combined read- and assembly-based metagenomics to reconstruct a Dehalococcoides mccartyi genome from PCB-contaminated sediments and evaluate functional differences among organohalide-respiring consortia in the presence of different halogenated contaminants.FEMS microbiology ecology · 2022Article
- Long-term survival ofFEMS microbes · 2022Article
- Detoxification of 1,1,2-trichloroethane to ethene by desulfitobacterium and identification of its functional reductase gene.PloS one · 2015Article
- Overview of organohalide-respiring bacteria and a proposal for a classification system for reductive dehalogenases.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013Review
- The physiological opportunism of Desulfitobacterium hafniense strain TCE1 towards organohalide respiration with tetrachloroethene.Applied and environmental microbiology · 2012Article
- Transcriptional analysis of a Dehalococcoides-containing microbial consortium reveals prophage activation.Applied and environmental microbiology · 2012Article
- Ecogenomics of microbial communities in bioremediation of chlorinated contaminated sites.Frontiers in microbiology · 2012Article
- Site-specific mobilization of vinyl chloride respiration islands by a mechanism common in Dehalococcoides.BMC genomics · 2011Article
- Facilitation of bacterial adaptation to chlorothalonil-contaminated sites by horizontal transfer of the chlorothalonil hydrolytic dehalogenase gene.Applied and environmental microbiology · 2011Article
- Cpl-7, a lysozyme encoded by a pneumococcal bacteriophage with a novel cell wall-binding motif.The Journal of biological chemistry · 2010Article
- The use of genomic signature distance between bacteriophages and their hosts displays evolutionary relationships and phage growth cycle determination.Virology journal · 2010Article
- Article
- Whole genome evaluation of horizontal transfers in the pathogenic fungus Aspergillus fumigatus.BMC genomics · 2010Article
- Localized plasticity in the streamlined genomes of vinyl chloride respiring Dehalococcoides.PLoS genetics · 2009Article
- Isolation and characterization of "Dehalococcoides" sp. strain MB, which dechlorinates tetrachloroethene to trans-1,2-dichloroethene.Applied and environmental microbiology · 2009Article
- Comparative genomics of "Dehalococcoides ethenogenes" 195 and an enrichment culture containing unsequenced "Dehalococcoides" strains.Applied and environmental microbiology · 2008Article
- A novel reductive dehalogenase, identified in a contaminated groundwater enrichment culture and in Desulfitobacterium dichloroeliminans strain DCA1, is linked to dehalogenation of 1,2-dichloroethane.Applied and environmental microbiology · 2007Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The genome of Dehalococcoides ethenogenes strain 195, an anaerobic dehalorespiring bacterium, contains 18 copies of putative reductive dehalogenase genes, including the well-characterized tceA gene, whose gene product functions as the key enzyme in the environmentally important dehalorespiration process. The genome of D. ethenogenes was analyzed using a bioinformatic tool based on the frequency of oligonucleotides. The results in the form of a genomic signature revealed several local disruptions of the host signature along the genome sequence. These fractures represent DNA segments of potentially foreign origin, so-called atypical regions, which may have been acquired by an ancestor through horizontal gene transfer. Most interestingly, 15 of the 18 reductive dehalogenase genes, including the tceA gene, were found to be located in these regions, strongly indicating the foreign nature of the dehalorespiration activity. The GC content and the presence of recombinase genes within some of these regions corroborate this hypothesis. A hierarchical classification of the atypical regions containing the reductive dehalogenase genes indicated that these regions were probably acquired by several gene transfer events.
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