ArticleThe Journal of physiology2005
Ca2+ permeability of nicotinic acetylcholine receptors in rat hippocampal CA1 interneurones.
Article in The Journal of physiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 47 citations in OpenAlex.
- Structural basis for a central permeation pathway in the P2X1 receptor.Cell discovery · 2026Article
- Axonal α7* nicotinic acetylcholine receptors modulate glutamatergic signaling and synaptic vesicle organization in ventral hippocampal projections.Frontiers in neural circuits · 2022Article
- Differential signalling induced by α7 nicotinic acetylcholine receptors in hippocampal dentate gyrus in vitro and in vivo.The Journal of physiology · 2021Article
- CaCells · 2020Review
- Nicotine Rescues Depressive-like Behaviors via α7-type Nicotinic Acetylcholine Receptor Activation in CaMKIV Null Mice.Molecular neurobiology · 2020Article
- Allosterically PotentiatedMolecular pharmacology · 2020Article
- Activation of microglia and astrocytes: a roadway to neuroinflammation and Alzheimer's disease.Inflammopharmacology · 2019Review
- Nicotine modulates human brain plasticity via calcium-dependent mechanisms.The Journal of physiology · 2018Article
- Effects of α7 Nicotinic Receptor Activation on Cell Survival in Rat Organotypic Hippocampal Slice Cultures.Neurotoxicity research · 2018Article
- The effect of α7 nicotinic receptor activation on glutamatergic transmission in the hippocampus.Biochemical pharmacology · 2015Review
- Neuronal Nicotinic Acetylcholine Receptor Structure and Function and Response to Nicotine.International review of neurobiology · 2015Review
- Nicotinic ACh receptors in the hippocampal circuit; functional expression and role in synaptic plasticity.The Journal of physiology · 2014Review
- A mutation in the extracellular domain of the α7 nAChR reduces calcium permeability.Pflugers Archiv : European journal of physiology · 2014Article
- Effects of neuronal nicotinic acetylcholine receptor allosteric modulators in animal behavior studies.Biochemical pharmacology · 2013Review
- Acetylcholine and antibodies against the acetylcholine receptor protect neurons and astrocytes against beta-amyloid toxicity.The international journal of biochemistry & cell biology · 2013Article
- Cholinergic receptors: functional role of nicotinic ACh receptors in brain circuits and disease.Pflugers Archiv : European journal of physiology · 2013Review
- Article
- Nicotinic ACh receptors in the hippocampus: role in excitability and plasticity.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2012Review
- Promoter methylation and tissue-specific transcription of the α7 nicotinic receptor gene, CHRNA7.Journal of molecular neuroscience : MN · 2012Article
- Addictive nicotine alters local circuit inhibition during the induction of in vivo hippocampal synaptic potentiation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
Corrections and comments
- Erratum issued
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Neuronal nicotinic acetylcholine receptors (nAChRs) are widely expressed in the brain where they are involved in a variety of physiological processes, including cognition and development. The nAChRs are ligand-gated cationic channels, and different subtypes are known to be differentially permeable to Ca2+; the alpha7-containing nAChRs are generally considered to be the most permeable. Ca2+ can activate and regulate a variety of signal transduction cascades, and the influx of Ca2+ through these receptors may have implications for synaptic plasticity. To determine the Ca2+ permeability of the nAChRs in rat hippocampal interneurones in the slice, which contain diverse subtypes of alpha7- and non-alpha7-containing nAChRs, we combined patch-clamp electrophysiology recordings with conventional fura-2 fluorescence imaging techniques. We estimated the relative Ca2+ permeability of the channels by determining the ratio of the increase in [Ca2+]i level (Delta[Ca2+]i) in the soma to the integrated transmembrane current (charge, Q) induced by the activation of the nAChRs, and compared this ratio to the highly Ca2+ permeable NMDA subtype of glutamate receptor channel. In all cells tested, the Delta[Ca2+]i/Q ratio was significantly larger (i.e. more than twice as big) for responses activated by NMDA than for alpha7-containing nAChRs in interneurones; the activation of the non-alpha7 nAChRs did not produce any significant increase in [Ca2+]i. Interestingly, the Ca2+ permeability of native alpha7 nAChRs in PC12 cells was significantly larger than in hippocampal interneurones, and not significantly different from NMDA receptors. Therefore, the alpha7-containing nAChRs in rat hippocampal interneurones are significantly less permeable to Ca2+ than not only NMDA receptors but also alpha7 nAChRs in PC12 cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.