Evidence map›Paper›PMID 15931378›Full record

ReviewThe Journal of clinical investigation2005

Genetic epidemiology of diabetes.

M Alan Permutt, Jonathon Wasson, Nancy Cox

Abstract readReview
In one paragraph

Review in The Journal of clinical investigation, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
88citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

88 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
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  6. Review
  7. Review
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  10. Article
  11. Article
  12. Association ofGlobal medical genetics · 2023
    Article
  13. Review
  14. Adenosine deaminase gene variant in diabetes and obesity.Journal of diabetes and metabolic disorders · 2022
    Article
  15. Review
  16. Article
  17. Article
  18. Type 1 diabetes: genes associated with disease development.Central-European journal of immunology · 2020
    Review
  19. Article
  20. Article

28 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

M Alan PermuttDepartment of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, St. Louis, Missouri 63110-1010, USA. apermutt@im.wustl.edu
Jonathon Wasson
Nancy Cox

Funding

CONSORTIUM LINKAGE STUDIES OF TYPE 2 DIABETESU01DK058026 · NIDDK · UNIVERSITY OF CHICAGO · PI COX, NANCY J. · 1999 to 2004
$7.5M
Metabolic Basis of Type 2 Diabetes Mellitus: a Genetic AnalysisR01DK049583 · NIDDK · WASHINGTON UNIVERSITY · PI PERMUTT, MARSHALL ALAN · 1996 to 2008
$3.1M
Metabolic Basis of Type 2 Diabetes Mellitus: a Genetic AnalysisR56DK049583 · NIDDK · WASHINGTON UNIVERSITY · PI PERMUTT, MARSHALL ALAN · 2006 to 2006
$92k
NIDDK NIH HHS DK049583NIDDK NIH HHS DK58026NIDDK NIH HHS R01 DK049583NIDDK NIH HHS R56 DK049583NIDDK NIH HHS U01 DK058026
6 · The paper itself

Abstract

Conventional genetic analysis focuses on the genes that account for specific phenotypes, while traditional epidemiology is more concerned with the environmental causes and risk factors related to traits. Genetic epidemiology is an alliance of the 2 fields that focuses on both genetics, including allelic variants in different populations, and environment, in order to explain exactly how genes convey effects in different environmental contexts and to arrive at a more complete comprehension of the etiology of complex traits. In this review, we discuss the epidemiology of diabetes and the current understanding of the genetic bases of obesity and diabetes and provide suggestions for accelerated accumulation of clinically useful genetic information.

Indexed as

Molecular EpidemiologyQuantitative Trait, HeritableDiabetes MellitusGenetic Predisposition to DiseaseGenetics, PopulationHumansObesityPrevalence

Identifiers

PMID15931378
PMCPMC1137004

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.