ReviewThe Journal of clinical investigation2005
Mapping the new frontier: complex genetic disorders.
Review in The Journal of clinical investigation, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- Highly penetrant alleles in age-related macular degeneration.Cold Spring Harbor perspectives in medicine · 2014Review
- Chapter 4: Protein interactions and disease.PLoS computational biology · 2012Article
- [Genetics of common chronic inflammatory skin diseases : An update on atopic dermatitis and psoriasis].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2011Article
- Genome-wide case/control studies in hypertension: only the 'tip of the iceberg'.Journal of hypertension · 2010Article
- Genetic aspects of Alzheimer disease.The neurologist · 2009Review
- Article
- Beyond the HapMap Genotypic Data: Prospects of Deep Resequencing Projects.Current bioinformatics · 2008Article
- A parallel genetic algorithm to discover patterns in genetic markers that indicate predisposition to multifactorial disease.Computers in biology and medicine · 2008Article
- The molecular genetic architecture of human personality: beyond self-report questionnaires.Molecular psychiatry · 2006Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The remarkable achievements in human genetics over the years have been due to technological advances in gene mapping and in statistical methods that relate genetic variants to disease. Nearly every Mendelian genetic disorder has now been mapped to a specific gene or set of genes, but these discoveries have been limited to high-risk, variant alleles that segregate in rare families. With a working draft of the human genome now in hand, the availability of high-throughput genotyping, a plethora of genetic markers, and the development of new analytical methods, scientists are now turning their attention to common complex disorders such as diabetes, obesity, hypertension, and Alzheimer disease. In this issue, the JCI provides readers with a series dedicated to complex genetic disorders, offering a view of genetic medicine in the 21st century.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.