ReviewClinical medicine & research2003
NSABP breast cancer clinical trials: recent results and future directions.
Review in Clinical medicine & research, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Hormone, Targeted, and Combinational Therapies for Breast Cancers: From Humans to Dogs.International journal of molecular sciences · 2024Pooled it
- Long-term outcomes by lobular vs ductal histology in 4 National Surgical Adjuvant Breast and Bowel Project adjuvant breast cancer trials.Journal of the National Cancer Institute · 2025Trial
- Randomized trial of adjuvant zoledronic acid in postmenopausal women with high-risk breast cancer.Clinical breast cancer · 2010Trial
- A Review of Breast Cancer Surgeries in a Sub-urban Nigerian Tertiary Hospital and the Limitations of Breast-Conserving Surgery.Breast cancer : basic and clinical research · 2025Article
- Allostatic load as a predictor of postoperative complications in patients with breast cancer.NPJ breast cancer · 2024Article
- Local Flaps in Breast-Conserving Surgery in Early Breast Cancer Patients: Armamentarium for Breast Surgeon.Indian journal of surgical oncology · 2024Article
- FAIR Health Informatics: A Health Informatics Framework for Verifiable and Explainable Data Analysis.Healthcare (Basel, Switzerland) · 2023Article
- Hispanic Ethnicity and Breast Cancer: Disaggregating Surgical Management and Mortality by Race.Journal of racial and ethnic health disparities · 2022Article
- The molecular heterogeneity of the precancerous breast affects drug efficacy.Scientific reports · 2022Article
- A Short History of Bernard Fisher's Contributions to Randomized Clinical Trials.Clinical trials (London, England) · 2022Article
- Breast Cancer Disparities and the Impact of Geography.Surgical oncology clinics of North America · 2022Review
- Choosing Mastectomy vs. Lumpectomy-With-Radiation: Experiences of Breast Cancer Survivors.Cureus · 2021Article
- The Potential Use of Tumour-Based Prognostic and Predictive Tools in Older Women with Primary Breast Cancer: A Narrative Review.Oncology and therapy · 2020Review
- Disparities in Breast Cancer: Private Patients Have Better Outcomes Than Public Patients.World journal of surgery · 2018Article
- Endocrine Therapy for Early Breast Cancer: Updated Review.Ochsner journal · 2017Review
- A Brief History of Breast Cancer: Part III - Tumour biology lays the foundation for medical oncology.Sultan Qaboos University medical journal · 2015Article
- Local recurrence rates are low in high-risk neoadjuvant breast cancer in the I-SPY 1 Trial (CALGB 150007/150012; ACRIN 6657).Annals of surgical oncology · 2014Observational
- Estrogen receptor (ER), progesterone receptor (PR), and HER2 expression pre- and post- neoadjuvant chemotherapy in primary breast carcinoma: a single institutional experience.International journal of clinical and experimental pathology · 2012Article
- Feasibility study of safe breast conservation in large and locally advanced cancers with use of radiopaque markers to mark pre-neoadjuvant chemotherapy tumor margins.World journal of surgery · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Over the past 40 years, the National Surgical Adjuvant Breast and Bowel Project (NSABP) has conducted several large, randomized clinical trials evaluating various aspects of surgical and adjuvant therapy in patients with operable breast cancer. Results from these trials have contributed significantly in reducing the extent of surgical procedures and in improving the outcome of patients with early-stage breast cancer. Furthermore, they have helped to establish standards of care for the surgical management of invasive and non-invasive disease and for the use of adjuvant hormonal therapy and adjuvant chemotherapy for patients with negative as well as for those with positive axillary nodes. More recent trials are evaluating several new classes of promising drugs such as the aromatase inhibitors in postmenopausal women with invasive or intraductal breast cancer, the taxanes for patients with positive nodes and in the neoadjuvant setting and other targeted molecular therapies such as trastuzumab and bisphosphonates. Results from these ongoing and recently completed trials could improve outcomes and quality of life for patients with early-stage breast cancer.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.