ArticleClinical medicine & research2003
Absence of Mycobacterium avium subspecies paratuberculosis components from Crohn's disease intestinal biopsy tissues.
Article in Clinical medicine & research, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- The zoonotic potential of Mycobacterium avium ssp. paratuberculosis: a systematic review and meta-analyses of the evidence.Epidemiology and infection · 2015Pooled it
- The zoonotic potential of Mycobacterium avium spp. paratuberculosis: a systematic review.Canadian journal of public health = Revue canadienne de sante publiquePooled it
- The Association of Mycobacterium avium subsp. paratuberculosis with Inflammatory Bowel Disease.PloS one · 2016Trial
- A comprehensive review of paratuberculosis in animals and its implications for public health.Open veterinary journal · 2024Review
- Australian Veterinarians' Perceptions Regarding the Zoonotic Potential ofVeterinary sciences · 2020Article
- Prevalence of Mycobacterium avium subspecies paratuberculosis IS 900 DNA in biopsy tissues from patients with Crohn's disease: histopathological and molecular comparison with Johne's disease in Fars province of Iran.BMC infectious diseases · 2019Article
- Current status ofThe Indian journal of medical research · 2016Review
- Article
- Intestinal microbiota pathogenesis and fecal microbiota transplantation for inflammatory bowel disease.World journal of gastroenterology · 2014Review
- Infectious etiopathogenesis of Crohn's disease.World journal of gastroenterology · 2014Review
- Mycobacterium avium subspecies paratuberculosis causes Crohn's disease in some inflammatory bowel disease patients.World journal of gastroenterology · 2014Review
- Article
- Mycobacterium avium subspecies Paratuberculosis and Crohn's regional ileitis: how strong is association?Journal of laboratory physicians · 2011Article
- Presence of intestinal Mycobacterium avium subspecies paratuberculosis (MAP) DNA is not associated with altered MMP expression in ulcerative colitis.BMC gastroenterology · 2011Article
- Presence of Mycobacterium avium subsp. paratuberculosis (MAP) in Brazilian patients with inflammatory bowel diseases and in controls.Sao Paulo medical journal = Revista paulista de medicinaArticle
- Absence of Mycobacterium avium ss paratuberculosis-specific IS900 sequence in intestinal biopsy tissues of Indian patients with Crohn's disease.Indian journal of gastroenterology : official journal of the Indian Society of GastroenterologyArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCrohn's disease is a chronic human intestinal inflammatory disorder for which an etiologic agent has not been identified. Johne's disease is a similar chronic enteric granulomatous disease of ruminant species and has been used as a model of Crohn's disease. Johne's disease has been proven to be caused by Mycobacterium avium subspecies paratuberculosis (M. avium ss paratuberculosis). It has been proposed that M. avium ss paratuberculosis may also cause Crohn's disease. This is of particular concern because the organism may be spread to humans through inadequately pasteurized dairy products.
objectiveWe sought to determine whether M. avium ss paratuberculosis could be detected using identical techniques in paraffin-embedded tissue samples of bovine Johne's disease and human Crohn's, ulcerative colitis and diverticular diseases. Samples were obtained for analysis from national tissue banks.
designCross-species and cross-disease sample comparisons by multiple detection techniques.
methodsHistology, immunocytochemistry and polymerase chain reaction (PCR) were utilized to test and compare the presence of M. avium ss paratuberculosis components. Insertion sequence IS900, present in multiple copies and found only in M. avium ss paratuberculosis, was utilized in both PCR and immunocytochemical analyses.
resultsThe IS900 sequence was demonstrable in all samples of confirmed positive Johne's disease tissue. The sequence was not identified in the 35 Crohn's, 36 ulcerative colitis, and 21 diverticular disease samples.
conclusionM. avium ss paratuberculosis was not associated with the lesions in these Crohn's disease samples, using these methods.
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