ReviewClinical medicine & research2003
Congenital and idiopathic scoliosis: clinical and genetic aspects.
Review in Clinical medicine & research, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 2 syntheses or guidelines pooled it, 137 citations in OpenAlex.
- Incidence of genitourinary anomalies in congenital scoliosis: systematic review and meta-analysis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2023Pooled it
- Incidence of intraspinal abnormalities in congenital scoliosis: a systematic review and meta-analysis.Journal of orthopaedic surgery and research · 2020Pooled it
- Article
- Whole-Exome Sequencing of Discordant Monozygotic Twins for Congenital Scoliosis: A Family Case Study.Genes · 2025Article
- Development and validation of a computable phenotype for adolescent idiopathic scoliosis.Learning health systems · 2025Article
- Advances in the diagnosis and treatment of congenital scoliosis.European journal of medical research · 2025Review
- Prevalence of scoliosis and congenital heart disease based on school screening in Jinghong City, Yunnan Province.Frontiers in public health · 2025Article
- Genetics and pathogenesis of scoliosis.North American Spine Society journal · 2024Article
- Fetal Scoliosis: Natural History and Outcomes.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2024Article
- Analysis of the factors affecting the loss of correction effect in patients with congenital scoliosis after one stage posterior hemivertebrae resection and orthosis fusion.BMC musculoskeletal disorders · 2023Article
- Ten-year trends in surgical management of 1207 congenital scoliosis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2023Article
- The L-type Amino Acid Transporter (LAT1) Expression in Patients with Scoliosis.Spine surgery and related research · 2022Article
- Cross-sectional analysis of associated anomalies and vertebral anomaly location in 1289 surgical congenital scoliosis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2021Article
- Older fusion-surgery age in congenital scoliosis patients is a risk factor for extended length of stay, more estimated blood loss, longer fused segments and higher medical costs: a retrospective study.BMC musculoskeletal disorders · 2021Article
- Identification of Copy Number Variants in a Southern Chinese Cohort of Patients with Congenital Scoliosis.Genes · 2021Article
- Cross-sectional analysis and trend of vertebral and associated anomalies in Chinese congenital scoliosis population: a retrospective study of one thousand, two hundred and eighty nine surgical cases from 2010 to 2019.International orthopaedics · 2021Article
- Collagen VI-related myopathy with scoliosis alone: A case report and literature review.World journal of clinical cases · 2021Article
- Incidence rate of congenital scoliosis estimated from a nationwide health insurance database.Scientific reports · 2021Article
- Identification of novel FBN1 variations implicated in congenital scoliosis.Journal of human genetics · 2020Article
- Regulation of terminal hypertrophic chondrocyte differentiation inDisease models & mechanisms · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveGenetic and environmental factors influencing spinal development in lower vertebrates are likely to play a role in the abnormalities associated with human congenital scoliosis (CS) and idiopathic scoliosis (IS). An overview of the molecular embryology of spinal development and the clinical and genetic aspects of CS and IS are presented. Utilizing synteny analysis of the mouse and human genetic databases, likely candidate genes for human CS and IS were identified.
designReview and synteny analysis.
methodsA search of the Mouse Genome Database was performed for "genes," "markers" and "phenotypes" in the categories Neurological and neuromuscular, Skeleton, and Tail and other appendages. The Online Mendelian Inheritance in Man was used to determine whether each mouse locus had a known human homologue. If so, the human homologue was assigned candidate gene status. Linkage maps of the chromosomes carrying loci with possibly relevant phenotypes, but without known human homologues, were examined and regions of documented synteny between the mouse and human genomes were identified.
resultsSearching the Mouse Genome Database by phenotypic category yielded 100 mutants of which 66 had been mapped. The descriptions of each of these 66 loci were retrieved to determine which among these included phenotypes of scoliosis, kinky or bent tails, other vertebral abnormalities, or disturbances of axial skeletal development. Forty-five loci of interest remained, and for 27 of these the comparative linkage maps of mouse and human were used to identify human syntenic regions to which plausible candidate genes had been mapped.
conclusionSynteny analysis of mouse candidate genes for CS and IS holds promise due to the close evolutionary relationship between mice and human beings. With the identification of additional genes in animal model systems that contribute to different stages of spine development, the list of candidate genes for CS and IS will continue to grow.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.