ReviewClinical medicine & research2003
Medical applications of transforming growth factor-beta.
Review in Clinical medicine & research, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 64 citations in OpenAlex.
- Effect of TGF-β3 on wound healing of bone cell monolayer in static and hydrodynamic shear stress conditions.Frontiers in medicine · 2024Article
- Understanding Scarring in the Oral Mucosa.Advances in wound care · 2022Review
- Utilizing the ABC Transporter for Growth Factor Production byBiomedicines · 2021Article
- BMP and TGFβ use and release in bone regenerationTurkish journal of medical sciences · 2020Review
- Evaluation of a Biocomposite Mesh Modified with Decellularized Human Amniotic Membrane for Intraperitoneal Onlay Mesh Repair.ACS omega · 2020Article
- Proteomic Identification and Time-Course Monitoring of Secreted Proteins During Expansion of Human Mesenchymal Stem/Stromal in Stirred-Tank Bioreactor.Frontiers in bioengineering and biotechnology · 2019Article
- Binding and biologic characterization of recombinant human serum albumin-eTGFBR2 fusion protein expressed in CHO cells.Bioengineered · 2017Article
- Sapylin promotes wound healing in mouse skin flaps.American journal of translational research · 2017Article
- Wound Healing Effects ofEvidence-based complementary and alternative medicine : eCAM · 2017Article
- The protective effect of hydrogen sulfide on systemic sclerosis associated skin and lung fibrosis in mice model.SpringerPlus · 2016Article
- The NR3C1 Glucocorticoid Receptor Gene Polymorphisms May Modulate the TGF-beta mRNA Expression in Asthma Patients.Inflammation · 2015Article
- Identification and association of the single nucleotide polymorphisms, C-509T, C+466T and T+869C, of the TGF-β1 gene in patients with asthma and their influence on the mRNA expression level of TGF-β1.International journal of molecular medicine · 2014Article
- SMAD3 gene variant is a risk factor for recurrent surgery in patients with Crohn's disease.Journal of Crohn's & colitis · 2014Article
- Current concepts in clinical radiation oncology.Radiation and environmental biophysics · 2014Review
- Critical Role of Transforming Growth Factor Beta in Different Phases of Wound Healing.Advances in wound care · 2013Review
- Role of TGF-β in Survival of Phagocytizing Microglia: Autocrine Suppression of TNF-α Production and Oxidative Stress.Experimental neurobiology · 2012Article
- Construction of eukaryotic expression plasmid of hTGF-β3 and its inducing effect on differentiation of precartilaginous stem cells into chondroblasts.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2011Article
- Article
- Apoptosis and expression of AQP5 and TGF-beta in the irradiated rat submandibular gland.Cancer research and treatment · 2009Article
- A forward chemical screen using zebrafish embryos with novel 2-substituted 2H-chromene derivatives.Chemical biology & drug design · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transforming growth factor-beta (TGF-beta) proteins and their antagonists have entered clinical trials. These multi-functional regulators of cell growth and differentiation induce extracellular matrix proteins and suppress the immune system making TGF-betas useful in treatment of wounds with impaired healing, mucositis, fractures, ischemia-reperfusion injuries, and autoimmune disease. In diseases such as keloids, glomerulonephritis and pulmonary fibrosis, excessive expression of TGF-beta has been implicated as being responsible for accumulation of detrimental scar tissue. In these conditions, agents that block TGF-beta have prevented or reversed disease. Similarly, in carcinogenesis, blocking TGF-beta activity may be valuable in stimulating an immune response towards metastasis. As these blocking agents receive approval, we will likely have new therapies for previously recalcitrant diseases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.