ArticleLearning & memory (Cold Spring Harbor, N.Y.)
Pontine stimulation overcomes developmental limitations in the neural mechanisms of eyeblink conditioning.
Article in Learning & memory (Cold Spring Harbor, N.Y.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 34 citations in OpenAlex.
- The Role of Cerebellar Intrinsic Neuronal Excitability, Synaptic Plasticity, and Perineuronal Nets in Eyeblink Conditioning.Biology · 2024Review
- Discrimination training affects stimulus generalization in mice during Pavlovian eyeblink conditioning.Frontiers in behavioral neuroscience · 2024Article
- Changes in membrane properties of rat deep cerebellar nuclear projection neurons during acquisition of eyeblink conditioning.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Cerebellar learning mechanisms.Brain research · 2015Review
- Ontogeny of septohippocampal modulation of delay eyeblink conditioning.Developmental psychobiology · 2015Article
- Extinction, reacquisition, and rapid forgetting of eyeblink conditioning in developing rats.Learning & memory (Cold Spring Harbor, N.Y.) · 2014Article
- Sensory system development influences the ontogeny of eyeblink conditioning.Developmental psychobiology · 2014Article
- Ontogeny of trace eyeblink conditioning to shock-shock pairings in the rat pup.Behavioral neuroscience · 2013Article
- Evaluation of bidirectional interstimulus interval (ISI) shift in auditory delay eye-blink conditioning in healthy humans.Learning & behavior · 2011Article
- Neural circuitry and plasticity mechanisms underlying delay eyeblink conditioning.Learning & memory (Cold Spring Harbor, N.Y.) · 2011Review
- Central cannabinoid receptors modulate acquisition of eyeblink conditioning.Learning & memory (Cold Spring Harbor, N.Y.) · 2010Article
- Ventral lateral geniculate input to the medial pons is necessary for visual eyeblink conditioning in rats.Learning & memory (Cold Spring Harbor, N.Y.) · 2010Article
- Medial auditory thalamic input to the lateral pontine nuclei is necessary for auditory eyeblink conditioning.Neurobiology of learning and memory · 2010Article
- Medial prefrontal administration of MK-801 impairs T-maze discrimination reversal learning in weanling rats.Behavioural brain research · 2009Article
- Spatial discrimination reversal learning in weanling rats is impaired by striatal administration of an NMDA-receptor antagonist.Learning & memory (Cold Spring Harbor, N.Y.) · 2009Article
- Intrahippocampal administration of an NMDA-receptor antagonist impairs spatial discrimination reversal learning in weanling rats.Neurobiology of learning and memory · 2009Article
- NMDA receptor involvement in spatial delayed alternation in developing rats.Behavioral neuroscience · 2009Article
- Neonatal binge alcohol exposure produces dose dependent deficits in interstimulus interval discrimination eyeblink conditioning in juvenile rats.Brain research · 2009Article
- Ontogenetic change in the auditory conditioned stimulus pathway for eyeblink conditioning.Learning & memory (Cold Spring Harbor, N.Y.) · 2008Article
- Eyeblink conditioning using cochlear nucleus stimulation as a conditioned stimulus in developing rats.Developmental psychobiology · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Pontine neuronal activation during auditory stimuli increases ontogenetically between postnatal days (P) P17 and P24 in rats. Pontine neurons are an essential component of the conditioned stimulus (CS) pathway for eyeblink conditioning, providing mossy fiber input to the cerebellum. Here we examined whether the developmental limitation in pontine responsiveness to a CS in P17 rats could be overcome by direct stimulation of the CS pathway. Eyeblink conditioning was established in infant rats on P17-P18 and P24-P25 using pontine stimulation as a CS. There were no significant age-related differences in the rate or level of conditioning. Eyeblink conditioned responses established with the stimulation CS were abolished by inactivation of the ipsilateral cerebellar nuclei and overlying cortex in both age groups. The findings suggest that developmental changes in the CS pathway play an important role in the ontogeny of eyeblink conditioning.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.