ArticleLearning & memory (Cold Spring Harbor, N.Y.)
A role for Synapsin in associative learning: the Drosophila larva as a study case.
Article in Learning & memory (Cold Spring Harbor, N.Y.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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38 citing papers in PubMed, 76 citations in OpenAlex.
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- Prediction error drives associative learning and conditioned behavior in a spiking model of Drosophila larva.iScience · 2024Article
- The Synergistic Effect of Thiamethoxam and Synapsin dsRNA Targets Neurotransmission to Induce Mortality inInternational journal of molecular sciences · 2022Article
- Daughterless, theDisease models & mechanisms · 2020Article
- Cellular and circuit mechanisms of olfactory associative learning inJournal of neurogenetics · 2020Review
- One-trial learning in larvalLearning & memory (Cold Spring Harbor, N.Y.) · 2019Article
- Memory enhancement by ferulic acid ester across species.Science advances · 2018Article
- Octopaminergic innervation and a neurohaemal release site in the antennal heart of the locust Schistocerca gregaria.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2018Article
- Associative Learning of Stimuli Paired and Unpaired With Reinforcement: Evaluating Evidence From Maggots, Flies, Bees, and Rats.Frontiers in psychology · 2018Article
- Aversive and Appetitive Learning inJournal of undergraduate neuroscience education : JUNE : a publication of FUN, Faculty for Undergraduate Neuroscience · 2018Article
- Secreted tissue inhibitor of matrix metalloproteinase restrictsJournal of cell science · 2017Article
- A Tyrosine-Hydroxylase Characterization of Dopaminergic Neurons in the Honey Bee Brain.Frontiers in systems neuroscience · 2017Article
- Genetic Dissection of Aversive Associative Olfactory Learning and Memory in Drosophila Larvae.PLoS genetics · 2016Article
- Sir2/Sirt1 Links Acute Inebriation to Presynaptic Changes and the Development of Alcohol Tolerance, Preference, and Reward.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Artificial Induction of Associative Olfactory Memory by Optogenetic and Thermogenetic Activation of Olfactory Sensory Neurons and Octopaminergic Neurons in Drosophila Larvae.Frontiers in behavioral neuroscience · 2016Article
- Synapsin is required to "boost" memory strength for highly salient events.Learning & memory (Cold Spring Harbor, N.Y.) · 2016Article
- Characterization of dopamine releasable and reserve pools in Drosophila larvae using ATP/P2X2 -mediated stimulation.Journal of neurochemistry · 2015Article
- Synapsin determines memory strength after punishment- and relief-learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Neuroprotective effect of biatractylenolide against memory impairment in D-galactose-induced aging mice.Journal of molecular neuroscience : MN · 2015Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Synapsins are evolutionarily conserved, highly abundant vesicular phosphoproteins in presynaptic terminals. They are thought to regulate the recruitment of synaptic vesicles from the reserve pool to the readily-releasable pool, in particular when vesicle release is to be maintained at high spiking rates. As regulation of transmitter release is a prerequisite for synaptic plasticity, we use the fruit fly Drosophila to ask whether Synapsin has a role in behavioral plasticity as well; in fruit flies, Synapsin is encoded by a single gene (syn). We tackled this question for associative olfactory learning in larval Drosophila by using the deletion mutant syn(97CS), which had been backcrossed to the Canton-S wild-type strain (CS) for 13 generations. We provide a molecular account of the genomic status of syn(97CS) by PCR and show the absence of gene product on Western blots and nerve-muscle preparations. We found that olfactory associative learning in syn(97CS) larvae is reduced to approximately 50% of wild-type CS levels; however, responsiveness to the to-be-associated stimuli and motor performance in untrained animals are normal. In addition, we introduce two novel behavioral control procedures to test stimulus responsiveness and motor performance after "sham training." Wild-type CS and syn(97CS) perform indistinguishably also in these tests. Thus, larval Drosophila can be used as a case study for a role of Synapsin in associative learning.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.