ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2005
Odorant-induced activation of extracellular signal-regulated kinase/mitogen-activated protein kinase in the olfactory bulb promotes survival of newly formed granule cells.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 36 citations in OpenAlex.
- Signaling mechanisms underlying activity-dependent integration of adult-born neurons in the mouse olfactory bulb.Genesis (New York, N.Y. : 2000) · 2024Review
- Genetic Increases in Olfactory Bulb BDNF Do Not Enhance Survival of Adult-Born Granule Cells.Chemical senses · 2020Article
- Transient Receptor Potential-canonical 1 is Essential for Environmental Enrichment-Induced Cognitive Enhancement and Neurogenesis.Molecular neurobiology · 2017Article
- Neuronal survival in the brain: neuron type-specific mechanisms.Cell death & disease · 2017Review
- A single identified glomerulus in the zebrafish olfactory bulb carries the high-affinity response to death-associated odor cadaverine.Scientific reports · 2017Article
- The type 3 adenylyl cyclase is required for the survival and maturation of newly generated granule cells in the olfactory bulb.PloS one · 2015Article
- Is integration and survival of newborn neurons the bottleneck for effective neural repair by endogenous neural precursor cells?Frontiers in neuroscience · 2014Article
- Article
- Tbr2 deficiency in mitral and tufted cells disrupts excitatory-inhibitory balance of neural circuitry in the mouse olfactory bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Neuropeptide Y and extracellular signal-regulated kinase mediate injury-induced neuroregeneration in mouse olfactory epithelium.Molecular and cellular neurosciences · 2012Article
- Neurogenesis drives stimulus decorrelation in a model of the olfactory bulb.PLoS computational biology · 2012Article
- Neuronal activity rapidly induces transcription of the CREB-regulated microRNA-132, in vivo.Hippocampus · 2010Article
- Turnover of newborn olfactory bulb neurons optimizes olfaction.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Learning and survival of newly generated neurons: when time matters.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Turning astrocytes from the rostral migratory stream into neurons: a role for the olfactory sensory organ.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Adult-born and preexisting olfactory granule neurons undergo distinct experience-dependent modifications of their olfactory responses in vivo.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Extracellular signal-regulated kinase 1/2 (Erk1/2)/mitogen-activated protein (MAP) kinase (MAPK) plays a significant role in neuronal survival, including odorant-induced, activity-dependent survival of olfactory sensory neurons in the main olfactory epithelium. Here, we examined the role of MAPK for the survival of neurons in the olfactory bulb. To study odorant-induced activation of MAPK in the olfactory bulb, mice were exposed to odorants in vivo, and MAPK was assayed. Exposure of mice to some odorants in vivo activated MAPK in granule cells 10 min after exposure. Activation of MAPK was particularly evident in the nucleus and dendrites of granule cells. Because MAPK activation can augment neuronal survival, odorant enhancement of granule cell survival was monitored by bromodeoxyuridine (BrdU) incorporation. Long-term exposure to odorants increased the survival of newly formed granule cells as well as the number of granule cells that were both BrdU+ and phospho-Erk+. Inhibition of MAPK by administration of SL327 in vivo blocked the odorant-induced increase in newly formed granule cells, suggesting that activation of MAPK promotes the survival of granule cells in the olfactory bulb. Studies using cultured granule cells confirmed that activation of MAPK in granule cells protects them against strong apoptotic signals. These data suggest that stimulation of MAPK in olfactory bulb granule cells by some odorants may contribute to the survival of newly formed granule cells caused by odorant exposure.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.