ArticleCancer research2005
BRCA2 suppresses cell proliferation via stabilizing MAGE-D1.
Article in Cancer research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 53 citations in OpenAlex.
- Decoding the Transcriptional Complexity of the Human BRCA2 DNA Repair Gene Using Hybrid-seq.Biochemical genetics · 2026Article
- Genetic Diversity, Population Structure and Differentiation of Farmed and Wild African Catfish (Evolutionary applications · 2026Article
- Characterization and functional analysis of BRCA1 and BRCA2 variants in a cohort of 100 unselected patients undergoing germline screening.Translational oncology · 2025Article
- Unique Transcriptomic Changes Underlie Hormonal Interactions During Mammary Histomorphogenesis in Female Pigs.Endocrinology · 2022Article
- Loss of smarcad1a accelerates tumorigenesis of malignant peripheral nerve sheath tumors in zebrafish.Genes, chromosomes & cancer · 2021Article
- RNA Methylation: A New Regulator of Vascular Remodeling in Pulmonary Hypertension.American journal of respiratory and critical care medicine · 2021Article
- Ranking cancer drivers via betweenness-based outlier detection and random walks.BMC bioinformatics · 2021Article
- Genetic and molecular bases of esophageal Cancer among Iranians: an update.Diagnostic pathology · 2019Review
- Expression dynamics ofOncotarget · 2019Article
- Complex roles of NRAGE on tumor.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Review
- Intracellular location of BRCA2 protein expression and prostate cancer progression in the Swedish Watchful Waiting Cohort.Carcinogenesis · 2016Article
- Maged1 co-interacting with CREB through a hexapeptide repeat domain regulates learning and memory in mice.Molecular neurobiology · 2015Article
- Prognostic relevance of melanoma antigen D1 expression in colorectal carcinoma.Journal of translational medicine · 2012Article
- Toward an integrative analysis of the tumor microenvironment in ovarian epithelial carcinoma.Cancer microenvironment : official journal of the International Cancer Microenvironment Society · 2012Article
- The melanoma-associated antigen-A3, -A4 genes: relation to the risk and clinicopathological parameters in breast cancer patients.Molecular and cellular biochemistry · 2011Article
- Skp2 overexpression is associated with loss of BRCA2 protein in human prostate cancer.The American journal of pathology · 2011Article
- Dlxin-1, a member of MAGE family, inhibits cell proliferation, invasion and tumorigenicity of glioma stem cells.Cancer gene therapy · 2011Article
- Homologs of breast cancer genes in plants.Frontiers in plant science · 2011Article
- Maged1, a new regulator of skeletal myogenic differentiation and muscle regeneration.BMC cell biology · 2010Article
- Cell cycle-dependent regulation of the bi-directional overlapping promoter of human BRCA2/ZAR2 genes in breast cancer cells.Molecular cancer · 2010Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Germ line mutations in BRCA2 gene predispose women to early-onset familial breast and ovarian cancer. BRCA2 is a protein of multiple functions. In addition to its role in DNA double-strand break repair, BRCA2 also plays a role in stabilization of stalled DNA replication forks, cytokinesis, transcription regulation, mammalian gametogenesis, centrosome duplication, and suppression of cell proliferation. However, how BRCA2 mutations predispose women specifically to breast and ovarian cancer remains undefined. Here we found that BRCA2 binds and stabilizes MAGE-D1, a member of the MAGE gene family of proteins. Expression of BRCA2 and MAGE-D1 synergistically suppresses cell proliferation independently of the p53 pathway. Using two MAGE-D1 RNA interferences and two cell lines expressing low or undetectable levels of MAGE-D1, we further showed that the expression of MAGE-D1 is required for BRCA2-mediated suppression of cell proliferation, indicating that MAGE-D1 is a downstream target of BRCA2 and that BRCA2 suppresses cell proliferation via stabilizing MAGE-D1. Importantly, MAGE-D1 protein expression was reduced in 6 of 16 breast carcinoma cell lines tested as compared with untransformed immortal mammary epithelial cell lines, suggesting that suppression of MAGE-D1 expression may be involved in the tumorigenesis of a subset of sporadic breast cancers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.