ArticleBMJ (Clinical research ed.)2005
Long term effects of hysterectomy on mortality: nested cohort study.
Article in BMJ (Clinical research ed.), 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Cardiovascular outcomes after hysterectomy: a systematic review and meta-analysis.Proceedings (Baylor University. Medical Center) · 2026Pooled it
- Association of Early Hysterectomy With Risk of Cardiovascular Disease in Korean Women.JAMA network open · 2023Article
- Association between hysterectomy status and stroke risk and cause-specific and all-cause mortality: evidence from the 2005-2018 National Health and Nutrition Examination Survey.Frontiers in neurology · 2023Article
- Relationship between hysterectomy and stroke in National Health and Nutrition Examination Survey (NHANES) 2007-2018: a cross-sectional study.Annals of translational medicine · 2022Article
- 1Menstruation: a possible independent health promoter, aging and COVID-19.Caspian journal of internal medicine · 2022Review
- What We Know about the Long-Term Risks of Hysterectomy for Benign Indication-A Systematic Review.Journal of clinical medicine · 2021Review
- The Association Between Hysterectomy and Ovarian Cancer Risk: A Population-Based Record-Linkage Study.Journal of the National Cancer Institute · 2019Article
- Hysterectomy is associated with higher risk of coronary artery disease: A nationwide retrospective cohort study in Taiwan.Medicine · 2018Observational
- Type and timing of menopause and later life mortality among women in the Iowa Established Populations for theEpidemiological Study of the Elderly (EPESE) cohort.Journal of women's health (2002) · 2012Article
- Cancer risk among users of oral contraceptives: cohort data from the Royal College of General Practitioner's oral contraception study.BMJ (Clinical research ed.) · 2007Article
- Hysterectomy for benign conditions.BMJ (Clinical research ed.) · 2005Article
Corrections and comments
- Commented on by
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo investigate the long term risk (mean > 20 years) of death from all causes, cardiovascular disease, and cancer in women who had or had not had a hysterectomy.
designNested cohort study.
settingRoyal College of General Practitioners' oral contraception study.
participants7410 women (3705 flagged at the NHS central registries for cancer and death who had a hysterectomy during the oral contraception study and 3705 who were flagged but did not have the operation).
main outcome measuresMortality from all causes, cardiovascular disease, and cancer.
results623 (8.4%) women had died by the end of follow-up (308 in the hysterectomy group and 315 in the non-hysterectomy group). Older women who had had a hysterectomy had a 6% reduced risk of death compared with women of a similar age who did not have the operation (adjusted hazard ratio 0.94, 95% confidence interval 0.75 to 1.18). Compared with young women who did not have a hysterectomy those who were younger at hysterectomy had an adjusted hazard ratio for all cause mortality of 0.82 (0.65 to 1.03). Hysterectomy was not associated with a significantly altered risk of mortality from cardiovascular disease or cancer regardless of age.
conclusionHysterectomy did not increase the risk of death in the medium to long term.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.