ArticleIntegrative physiological and behavioral science : the official journal of the Pavlovian Society
Eyeblink conditioning in rats using pontine stimulation as a conditioned stimulus.
Article in Integrative physiological and behavioral science : the official journal of the Pavlovian Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 34 citations in OpenAlex.
- Training on multiple days results in better learning in embedded eyeblink conditioning in young human adults.NPJ science of learning · 2025Article
- The Effect of Nucleo-Olivary Stimulation on Climbing Fiber EPSPs in Purkinje Cells.Cerebellum (London, England) · 2024Article
- Discrimination training affects stimulus generalization in mice during Pavlovian eyeblink conditioning.Frontiers in behavioral neuroscience · 2024Article
- Disruption of rat deep cerebellar perineuronal net alters eyeblink conditioning and neuronal electrophysiology.Neurobiology of learning and memory · 2021Article
- Morphological Constraints on Cerebellar Granule Cell Combinatorial Diversity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Article
- Enhancement of delay eyelid conditioning by microcurrent electrical stimulation of the medial prefrontal cortex is triggered by the expression of Fos protein in guinea pigs.Experimental and therapeutic medicine · 2016Article
- Cerebellar learning mechanisms.Brain research · 2015Review
- Species-specific differences in the medial prefrontal projections to the pons between rat and rabbit.The Journal of comparative neurology · 2014Article
- Classical eyeblink conditioning using electrical stimulation of caudal mPFC as conditioned stimulus is dependent on cerebellar interpositus nucleus in guinea pigs.Acta pharmacologica Sinica · 2012Article
- Evaluation of bidirectional interstimulus interval (ISI) shift in auditory delay eye-blink conditioning in healthy humans.Learning & behavior · 2011Article
- Neural circuitry and plasticity mechanisms underlying delay eyeblink conditioning.Learning & memory (Cold Spring Harbor, N.Y.) · 2011Review
- Ventral lateral geniculate input to the medial pons is necessary for visual eyeblink conditioning in rats.Learning & memory (Cold Spring Harbor, N.Y.) · 2010Article
- Cerebellar and extracerebellar involvement in mouse eyeblink conditioning: the ACDC model.Frontiers in cellular neuroscience · 2010Article
- Medial auditory thalamic input to the lateral pontine nuclei is necessary for auditory eyeblink conditioning.Neurobiology of learning and memory · 2010Article
- Shortened conditioned eyeblink response latency in male but not female Wistar-Kyoto hyperactive rats.Behavioral neuroscience · 2009Article
- Stimulation of the lateral geniculate, superior colliculus, or visual cortex is sufficient for eyeblink conditioning in rats.Learning & memory (Cold Spring Harbor, N.Y.) · 2009Article
- Ontogenetic change in the auditory conditioned stimulus pathway for eyeblink conditioning.Learning & memory (Cold Spring Harbor, N.Y.) · 2008Article
- Medial auditory thalamus inactivation prevents acquisition and retention of eyeblink conditioning.Learning & memory (Cold Spring Harbor, N.Y.) · 2008Article
- Inferior colliculus lesions impair eyeblink conditioning in rats.Learning & memory (Cold Spring Harbor, N.Y.) · 2007Article
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2 authors at 1 institution in 1 country.
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Abstract
Previous studies using rabbits and ferrets found that electrical stimulation of the pontine nuclei or middle cerebellar peduncle could serve as a conditioned stimulus (CS) in eyeblink conditioning (Bao, Chen, & Thompson, 2000; Hesslow, Svensson, & Ivarsson, 1999; Steinmetz, 1990; Steinmetz, Lavond, & Thompson, 1985; 1989; Steinmetz et al., 1986; Tracy, Thompson, Krupa, & Thompson, 1998). The current study used electrical stimulation of the pontine nuclei as a CS to establish eyeblink conditioning in rats. The goals of this study were to develop a method for directly activating the CS pathway in rodents and to compare the neural circuitry underlying eyeblink conditioning in different mammalian species. Rats were given electrical stimulation through a bipolar electrode implanted in the pontine nuclei paired with a periorbital shock unconditioned stimulus (US). Paired training was followed by extinction training. A subset of rats was given a test session of paired training after receiving an infusion of muscimol into the anterior interpositus nucleus. Rats given paired presentations of the stimulation CS and US developed CRs rapidly and showed extinction. Muscimol infusion prior to the test session resulted in a reversible loss of the eyeblink CR. The results demonstrate that electrical stimulation of the pontine nuclei can be used as a CS in rodents and that the CS pathway is similar in rats, rabbits, and ferrets. In addition, the loss of CRs following muscimol inactivation shows that the conditioning produced with pontine stimulation depends on cerebellar mechanisms.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.