Evidence map›Paper›PMID 15928666›Full record

ArticleBritish journal of cancer2005

Monitoring of circulating tumour-associated DNA as a prognostic tool for oral squamous cell carcinoma.

K Hamana, K Uzawa, K Ogawara, M Shiiba, H Bukawa, H Yokoe, H Tanzawa

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of cancer, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06163534 (TEMPUS PHOENIX HNSCC STUDY), which is not on this map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06163534 recruitingnot on this mapstarted 2024, after this paper: background citation

TEMPUS PHOENIX HNSCC STUDY: A Longitudinal Multi-Omic Biomarker Profiling Study of Patients With Head & Neck Squamous Cell Carcinoma (HNSCC)

Typeobservational_patient_registrySponsorTempus AIRan2024 to 2028Enrolled500ConditionsHead and Neck Squamous Cell Carcinoma
3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Review
  14. Liquid Biopsy in Oral Cancer.International journal of molecular sciences · 2018
    Review
  15. Review
  16. Review
  17. Review
  18. Review
  19. Role of Circulating Cell-Free DNA in Cancers.Molecular diagnosis & therapy · 2015
    Review
  20. Liquid biopsy: monitoring cancer-genetics in the blood.Nature reviews. Clinical oncology · 2013
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

K HamanaDepartment of Clinical Molecular Biology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan.
K Uzawa
K Ogawara
M Shiiba
H Bukawa
H Yokoe
H Tanzawa

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Frequent allelic imbalances (AIs) including loss of heterozygosity and microsatellite instability on a specific chromosomal region have been identified in a variety of human malignancies. The objective of our study was to assess the possibility of prognostication and monitoring of oral squamous cell carcinoma (SCC) by microsatellite blood assay. DNA from normal and tumorous tissues and serum DNA obtained at three time points (preoperatively, postoperatively, and 4 weeks postoperatively) from 64 patients with oral SCC was examined at nine microsatellite loci. In all, 38 (59%) DNA samples from tumorous tissues and 52% from serum showed AIs in at least one locus. Patterns of AIs in the serum DNA were matched to those detected in tumour DNA. Of them, AIs were frequently detected preoperatively (44%, 28 of 64), and postoperatively (20%, 13 of 64). Moreover, among 12 cases with AIs during the postoperative period, six had no evidence of an AI 4 weeks postoperatively, and they had no recurrence and were disease free. In contrast, six patients with AI-positive DNA 4 weeks postoperatively have died with distant metastasis within 44 weeks. Thus, our results suggest that the assessment of microsatellite status in the serum DNA could be a useful predictive tool to monitor disease prognosis.

Indexed as

Neoplastic Cells, CirculatingAdultAgedAged, 80 and overAllelic ImbalanceCarcinoma, Squamous CellDNA, NeoplasmFemaleHumansMaleMicrosatellite RepeatsMiddle AgedMouth NeoplasmsNeoplasm StagingPilot ProjectsPrognosisDNA, Neoplasm

Identifiers

PMID15928666
PMCPMC2361808

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.